环丙沙星和磺胺间甲氧嘧啶联合用药在猪体内的血浆药动学  

Pharmacokinetics of ciprofloxacin and sulfamonomethoxine by combinational injection in swine

作　　者：张巧艳[1] 林晶[2] 毛江昌 汪建妹[1] 吉小凤[1] 钱鸣蓉[1] 

机构地区：[1]浙江省农业科学院农产品质量标准研究所,浙江杭州310021 [2]杭州师范大学大型仪器公共服务平台,浙江杭州311121 [3]杭州京奥农业开发有限公司,浙江杭州311215

出　　处：《中国兽医学报》2014年第4期601-605,共5页Chinese Journal of Veterinary Science

基　　金：浙江省公益技术应用研究资助项目(2012C22069)

摘　　要：采用高剂量CIP(20mg/kg体质量)和SMM(100mg/kg体质量)联合肌注给药,同步检测试验猪各采血点的血药浓度,通过DAS药物动力学程序软件分析血药浓度—时间数据。结果显示:CIP和SMM在联用时药时数据均符合一级吸收二室开放模型,CIP主要的药动学参数:t1/2为(4.98±0.60)h,Vd为(6.61±0.81)L/kg,AUC为(21.79±1.01)(mg/L)·h,Cmax为(7.56±0.26)mg/L,t1/2Ka为(0.93±1.86)h;SMM主要的药动学参数:t1/2为(4.98±0.92)h,Vd为(1.06±0.19)L/kg,AUC为(679.99±13.17)(mg/L)·h,Cmax为(72.75±3.26)mg/L,t1/2Ka为(0.72±0.36)h。联合用药符合生产中多种药共用的情况,为以后多类属药物残留消除规律研究提供参考。The pharmacokinetie characteristics of ciprofloxacin （CIP） and sulfamonomethoxine （SMM） were investigated in plasma of swine after combinational intramuscular injection of CIP （20 mg/kg bw） and SMM （100 mg/kg bw）. Blood samples were collected at different intervals after injection and the concentrations of CIP and SMM were determined by a simultaneous detection method based on HPLC-UV. The pharmacokinetic program DAS was used to analyze the concentration-time data. The results showed that the concentration-time data of CIP and SMM were both described by a one-com- partment open model with first-order absorption. The main pharmacokinetic parameters of CIP were as follows：t1/2 ,（4.98±0.60） h;Vd,（6.61±0.81） L/kg;AUC, （21. 79±1.01） （mg/L）· h,C （7.56±0.26） mg/L; t1/2Ka, （0.93±1.86） h. The main pharmacokinetic parameters of SMM were as follows：tl/2, （4. 98±0. 92） h;Vd ,（1.06±0. 19） L/kg;AUC,（679. 99±13.17） （rag/L）·h,Cmax, （72.75±3.26） rag/L; t1/2Ka ,（0. 72±0. 36） h. The combinational administration which is different from respective adminis- tration could provide the background for the residues elimination law of multi-class antibimics in tissues.

关 键 词：联合给药 环丙沙星 磺胺间甲氧嘧啶 猪 药代动力学 同步检测 

分 类 号：S859.79[农业科学—临床兽医学]