多臂星形聚乙烯亚胺的设计合成及聚合动力学  

Design,Synthesis and Polymerization Kinetics of Star-Like Polyethylenimine

作　　者：何宁[1] 孙贺春 董晓曼[1] 徐欢喜 

机构地区：[1]安徽中医药大学药学院,安徽合肥230031

出　　处：《高分子材料科学与工程》2014年第7期35-39,共5页Polymer Materials Science & Engineering

基　　金：安徽省高等学校省级自然科学研究重点项目(KJ2012A182);安徽中医药大学药学院药苑之星科研基金(201210)

摘　　要：非病毒基因载体聚乙烯亚胺结构不可控,同时最优结构未知,因此文中采用Core-First的方法,以三氟甲磺酸酯作为引发剂,通过2-乙基-2-恶唑啉阳离子开环聚合合成了二臂、四臂、六臂和八臂星形聚乙烯亚胺。利用核磁共振氢谱、凝胶渗透色谱仪对合成的星形聚合物的结构、相对分子质量及其分布进行了表征,并对2-乙基-2-恶唑啉的开环聚合动力学进行了研究。结果表明,合成得到了结构明确、窄分散的多臂星形聚乙烯亚胺,且该聚合反应符合活性聚合的特征。A novel star-like non-viral gene carrier polyethylenimine was prepared via living cationic ring-opening polymerization of 2-ethyl-2-oxazoline initiated by trifluoromethylsulfonate. The molecular structure of the resulting polymer was confirmed by 1H nuclear magnetic resonance spectroscopy （NMR）. The molar masses and polydispersity of synthesized polymer were characterized by gel permeation chromatography. Polymerization kinetics results indicate that the apparent polymerization rate increases linearly with the number of initiating groups per molecule and the initiating groups of initiators E- H are of equal reactivity for the polymerization initiation of 2-ethyl-2-oxazoline. Thus all initiators are of the same reactivity and all arms grow at the same rate. This method leads to polymers with controlled molecular weights and narrow molecular weight distributions.

关 键 词：非病毒基因载体 聚乙烯亚胺 三氟甲磺酸酯 聚合动力学 2-乙基-2-恶唑啉 

分 类 号：TQ316.339[化学工程—高聚物工业]