2012年成都市健康人群流脑A群和C群抗体水平监测分析  

Surveillance of Antibody Level of Epidemic Cerebrospinal Meningitis Group A and Group C in Healthy Population in Chengdu

作　　者：杨汝沛[1] 郑珂[1] 张晓春[1] 朱宝[1] 胡燕[2] 邓丽[3] 郑尚义 

机构地区：[1]成都市疾病预防控制中心,成都610041 [2]成都市青羊区疾病预防控制中心 [3]成都市双流县疾病预防控制中心 [4]成都市蒲江县疾病预防控制中心

出　　处：《预防医学情报杂志》2014年第8期627-630,共4页Journal of Preventive Medicine Information

摘　　要：目的了解成都市健康人群流脑A群和C群抗体水平,为采取有效的预防控制措施提供科学依据。方法按分层抽样方法采集6个年龄组623名健康人群的血清标本检测流脑A群和C群IgG抗体。结果成都市健康人群中流脑A群抗体阳性率为90.05%,流脑C群抗体阳性率为58.59%,两者差异有统计学意义（χ2=161.53,P〈0.01）。不同年龄组健康人群中A群抗体保护率15~19岁组96.70%最高、0~2岁组77.86%最低,0~2岁流脑A群抗体保护率与其他年龄组差异有统计学意义（P〈0.01）。不同年龄组健康人群中C群抗体保护率3~4岁组75.44%最高、7~14岁组32.89%最低,0~6岁与7岁以上年龄组健康人群中流脑C群抗体保护率差异有统计学意义（P〈0.01）。结论成都市健康人群中流脑A群抗体水平维持在较高水平,短期内发生流脑A群暴发流行的可能性较低。流脑C群抗体水平较低且存在流脑C群菌自然感染状态,有发生流脑C群暴发流行的可能,因此在做好儿童流脑A＋C群多糖疫苗常规免疫接种和儿童入托、入学预防接种证查验补种的同时,要注意监外来人口聚居区流脑疫情变化及早开展防控工作。Objective To investigate the cerebrospinal meningitis antibody level in healthy population in Cheng- du, and provide scientific basis for preventing eerebrospinal meningitis. Methods Stratified sampling was used to recruit a total of 623 healthy individuals, whose serum specimen were tested for IgG antibody of epidemic ce- rebrospinal meningitis group A and group C. Results The positive rate of meningitis group A antibody in the healthy people of Chengdu was 90. 05% , while in the group C was 58.59% , with statistically difference be- tween the two （χ2 = 161.53, P 〈0.01）. Among the different age groups of group A antibody, the antibody protection rate of group aged 15 - 19 was the highest （ 96. 70% ） ; the group of 0 - 2 was the lowest （77.86%） and was statistically different from other age groups （P 〈0.01 ）. Among the different age groups of group C antibody, the antibody protection rate in group of 3 - 4 years old was the highest （75.44%）, while in group aged 7 - 14 years old was the lowest （32.89%）. The difference of protection rates between group 0 -6 years old and 7 - were statistically different （P 〈 0. 01 ）. Conclusion The cerebrospinal meningitis antibody level of the healthy population in Chengdu maintains at a high level, thus the outbreak of meningitis group A is unlikely to happen in a short term. However, the antibody of Group C is lower and the natural in- fection of group C exists, which may indicate a higher possibility of outbreak. Thus, the immunization of men- ingitis A ＋ C among children need to be strengthened, especially the inspection of vaccination certificate at the school and kindergarten beginnings. Besides, the surveillance in the floating people should be taken into con- sideration as well.

关 键 词：健康人群 流脑抗体水平 监测 

分 类 号：R512.3[医药卫生—内科学]