乳化-溶剂挥发法制备聚乳酸载药微球  

Make microspheres through emulsion-solvent evaporation method

作　　者：邵文尧[1] 何彩云[1] 冯艳玲[1] 陈玉清[1] 

机构地区：[1]厦门大学化学化工学院,福建厦门361005

出　　处：《功能材料》2015年第3期3121-3126,共6页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(21406185);福建省科技计划重点资助项目(2013H0043)

摘　　要：采用o/w型乳化-溶剂挥发法来制备载药微球,以二氯甲烷为溶剂相,以聚乳酸为载体材料,以维A酸为包埋药物,以吐温-80和明胶为乳化剂。探索载药微球制备过程中的变量(高剪切转速、高剪切时间、内外相体积比、壁材用量等)对载药微球粒径大小、包封率以及稳定性等的影响。得出最优载药微球制备方案:明胶浓度7.5mg/mL,吐温浓度6mg/mL,聚乳酸浓度10 mg/mL,内外相体积比1∶10,剪切时间30min,搅拌速度300r/min,挥发时间3h。所制得的聚乳酸载药微球形态光滑且分散性较好,包封率为52.42%。In this study,o/w emulsion-solvent evaporation method was used to make microspheres,using dichlo-romethane as the solvent phase,polylactic acid as the carrier material and vitamin A acid as the entrapped ob-ject,tween 80 and gelatine as emulsifier.The technical conditions such as shear speed,shear time,internal,ex-ternal phase volume ratio and the amount of wall material were determined.The experiments demonstrated that the optimal conditions were:gelatin concentration of 7 .5 mg/mL,tween concentration of 6 mg/mL,polylactic acid concentration of 10 mg/mL,inside and outside the phase volume ratio of 1∶10,shearing time of 30 min, stirring speed of 300 r/min,volatile time of 3 h.The final product was smooth and well dispersed,and the en-capsulation efficiency was 52.42%.

关 键 词：载药微球 o/w乳化G溶剂挥发法 聚乳酸 维A酸 包封率 

分 类 号：TB332[一般工业技术—材料科学与工程]