出生前后DEHP暴露对小鼠神经行为的影响  

Effects of utero and lactational exposure to di-(2-ethylhexyl) phthalate on neurobehavior of offspring mice

作　　者：徐晓虹[1] 竹庆杰 杨艳玲[1] 阮琴[1] 

机构地区：[1]浙江师范大学化学与生命科学学院生态研究所,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2015年第1期15-22,共8页Journal of Zhejiang Normal University:Natural Sciences

摘　　要：研究了增塑剂邻苯二甲酸二(2-乙基)己酯(di-(2-ethyl hexyl)phthalate,DEHP)围生期母体暴露对青春期(6周龄)和成年后部(12周龄)子代小鼠行为的影响.母鼠从妊娠第7天至断乳前(产后21 d)灌胃染毒DEHP(10,50和200 mg/(kg·d)),同时设空白对照组及溶媒对照组.出生后第6和第12周时分别检测仔鼠的活动性、焦虑、空间记忆等行为.结果显示:DEHP暴露显著抑制了青春期雌、雄仔鼠的活动性,增加了其焦虑状态,且加剧的焦虑状态可延续到成年后的雌鼠;损伤青春期雄鼠的空间学习记忆能力,但对青春期雌鼠和成年后雌、雄仔鼠的空间记忆能力没有影响.以上结果提示,发育期DEHP暴露性别特异性地影响仔鼠的多种神经行为,青春期的情感和记忆能力更容易受影响.The present study investigated the effects of utero and lactational exposure to DEHP （10, 50, and 200 mg/（ kg·d） ） from gestation day 7 through postnatal day 21 on the behavior of offspring mice at age of 6 and 12 weeks. The results showed that DEHP exposure significantly inhibited locomotion but increased anxie-ty-like state of pubertal offspring mice of both sexes, and permanently influenced anxiety-like state of females in adulthood. Utero and lactational exposure to DEHP impaired spatial learning and memory function in puber-tal male mice, but not in pubertal females and adult mice of both sexes. These results suggested that develop-mental DEHP exposure sex specifically influenced a variety of neurobehavior, and anxiety and memory of pu-berty were more susceptible to DEHP.

关 键 词：邻苯二甲酸二乙基己酯 焦虑 学习记忆 神经行为 

分 类 号：R395.4[哲学宗教—心理学]