NSICU鲍氏不动杆菌感染分布及耐药性分析  

Analysis of infection distribution and drug resistance of Acinetobacter baumannii in the neurosurgical intensive care unit

作　　者：周祥[1] 惠红岩[2] 陈明[2] 金保哲[1] 黄立勇[1] 惠磊[1] 王仲伟[1] 周文科[1] 

机构地区：[1]新乡医学院第一附属医院神经外科,河南卫辉453100 [2]新乡医学院第一附属医院药剂科,河南卫辉453100

出　　处：《中华医院感染学杂志》2014年第23期5740-5742,共3页Chinese Journal of Nosocomiology

基　　金：河南省教育厅自然科学基金资助项目(12A320012)

摘　　要：目的了解神经外科重症监护病房(NSICU)鲍氏不动杆菌的分布及耐药性变迁,为临床治疗提供依据。方法分析2009年1月-2012年12月106株鲍氏不动杆菌的分布及药敏试验结果,收集数据进行统计分析,采用WHONIT 5.6软件进行统计分析。结果 106例患者中以重症脑血管疾病为主,共51例占48.1%;共分离出106株鲍氏不动杆菌,以痰标本为主,共74株占69.8%;分离菌株对头孢唑林、氨苄西林、哌拉西林及磺胺甲噁唑/甲氧苄啶的耐药率均>90.0%,对多黏菌素敏感率均为100.0%。结论鲍氏不动杆菌对多种抗菌药物呈多药耐药性,应加强对鲍氏不动杆菌耐药性的检测,加强NSICU的消毒和管理,加强医务人员的手卫生,合理应用抗菌药物。OBJECTIVE To investigate the distribution and changes in drug resistance of clinical isolates of Acineto‐bacter baumannii from the neurosurgical intensive care unit （NSICU ） ,and to provide evidence for the clinical ther‐apy for infections .METHODS The distribution and results of drug sensitive test to 18 antibiotics of 106 strains of A .baumannii were analyzed .Data were collected for statistical analysis with the WHONIT 5 .6 software . RESULTS Severe cerebrovascular disease （51 cases ,48 .1% ） was the main disease among the 106 patients .Total‐ly 106 strains of A .baumannii were isolated ,mainly from sputum specimens （74 strains ,69 .8% ） .The resistant rates of the isolated strains were more than 90 .0% to cefazolin ,ampicillin ,piperacillin ,and sulfamethoxazole/tri‐methoprim and 100 .0% to polymyxin .CONCLUSION A .baumannii had multiple resistances to several antimicro‐bials .Monitoring for drug resistance of A .baumannii should be strengthened ,as well as the disinfection and man‐agement of NSICU ,hand disinfection of medical staffs should be improved ,and antimicrobial drugs should be used more rationally .

关 键 词：神经外科重症监护病房 鲍氏不动杆菌 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]