帕金森病患者幽门螺杆菌感染对血清氧化应激状态及血小板线粒体功能的影响  

Effect of Helicobacter pylori infection on serum oxidative stress and platelet mitochondrial function in patients with Parkinson′s disease

作　　者：范崇桂[1] 付国惠[1] 闪海霞[1] 

机构地区：[1]南阳市中心医院神经内科,河南南阳473000

出　　处：《中华医院感染学杂志》2014年第23期5783-5785,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技攻关计划基金项目(0211043700)

摘　　要：目的观察帕金森病患者(PD)幽门螺杆菌(Hp)感染对血清氧化应激状态及血小板线粒体功能的影响,探讨Hp感染导致PD发生的机制,为临床治疗提供参考依据。方法随机抽选2008年3月-2012年5月47例PD患者为研究组,并抽选同期非PD患者52例为对照组进行对照研究,比较两组患者血清中Hp-IgG抗体类型、血小板线粒体ComplexⅠ活性、还原型谷胱甘肽(GSH)以及丙二醛(MDA)水平的差异。结果研究组Hp抗体Ⅰ型比例及总阳性率显著高于对照组(P<0.05),研究组患者的血小板线粒体ComplexⅠ活性明显低于对照组(P<0.05);两组血清GSH以及MDA含量比较差异无统计学意义;研究组中Hp阳性患者ComplexⅠ活性以及血清MDA含量与对照组中Hp阴性患者比较差异均有统计学意义(P<0.05);血清GSH在各组中比较差异均无统计学意义。结论 Hp感染可引起PD患者线粒体功能损伤,产生氧化应激状态,可能参与了PD的发病机制。OBJECTIVE To observe the effect of Helicobacter pylori （Hp） infection on serum oxidative stress and the platelet mitochondrial function in patients with Parkinson′s disease （PD） ,explore the mechanism of HP infec‐tion causing PD and provide reference for clinical treatment .METHODS Totally 47 PD patients during Mar .2008 to May 2012 were randomly chosen as the research group ,and 52 non PD patients during the same period were chosen as the control group .The differences in serum HP‐IgG antibody types ,platelet Complex Ⅰ activity , reduced glutathione （GSH） and malondialdehyde （MDA） level between the two groups of patients were compared . RESULTS The proportion of Hp antibody type Ⅰ and the total positive rate were significantly higher in the re‐search group than in the control group （P〈0 .05） .Platelet Complex Ⅰ activity was significantly lower in the re‐search group than that in the control group （P〈0 .05） .There was no significant difference in serum GSH and MDA content between the two groups .There was significant difference in the serum MDA content and ComplexⅠ activity between the research group （Hp＋ ） and the control group （Hp-） （P〈0 .05） .There was no signifi‐cant difference in the serum level of GSH between each group .CONCLUSION HP infection would damage mito‐chondrial function and lead to oxidative stress ,which may be involved in the onset mechanism of PD .

关 键 词：氧化应激 幽门螺杆菌 线粒体功能 帕金森 

分 类 号：R378[医药卫生—病原生物学]