泌尿生殖道支原体属感染及药敏结果分析  

Urogenital tract infection caused by Mycoplasmaand analysis of drug sensitivity

作　　者：刘家芹[1] 储新民[1] 马筱玲[1] 蒋法兴[2] 

机构地区：[1]安徽省立医院检验科,安徽合肥230001 [2]安徽省立医院皮肤科,安徽合肥230001

出　　处：《中华医院感染学杂志》2014年第23期5789-5790,5796,共3页Chinese Journal of Nosocomiology

基　　金：安徽省自然科学基金资助项目(090413143);安徽省重点科研基金资助项目(11010403054)

摘　　要：目的分析解脲脲支原体(Uu)和人支原体(Mh)在泌尿生殖道的感染状况及药物敏感性,为临床合理选用抗菌药物提供依据。方法采用支原体属培养、鉴定、药敏一体化试剂盒对5 972例临床疑似患者送检的泌尿生殖道标本进行支原体属计数培养、鉴定及药物敏感试验,采用SPSS10.0进行统计分析。结果 5 972份标本中支原体属培养阳性1 641例,阳性率27.5%,Uu、Mh、Uu+Mh的分布分别占78.3%、1.7%、20.0%;Uu、Mh、Uu+Mh三类感染对13种抗菌药物的耐药性不同,Uu对林可霉素耐药率最高为98.0%,其次是环丙沙星和诺氟沙星,耐药率分别为81.2%和70.6%;Uu+Mh混合感染时对林可霉素、环丙沙星、诺氟沙星、阿奇霉素、罗红霉素、克拉霉素、司帕沙星耐药率均在70.0%以上。结论泌尿生殖道支原体感染以Uu感染为主,且耐药性严重,临床医师应参照药敏结果合理选用抗菌药物。OBJECTIVE To analyze the infection status and antimicrobial susceptibility of Ureaplsma urealyticum （Uu） and Mycoplasma hominis （Mh） in urogenital tract ,and provide a basis for clinical rational selection of drugs .METHODS Using culture ,identification ,drug sensitivity integration kit ,Mycoplasma culture and anti‐microbial susceptibility test were performed on the urogenital tract specimens of 5 972 patients with suspected My‐coplasma infection ,statistical analysis was performed with SPSS10 .0 statistical software .RESULTS In the total of 5972 inspected specimens ,1641 cases were positive with a positive rate of 27 .5% .The positive rate of Uu ,and Mh was 78 .3% ,and 1 .7% respectively and the positive rate of Uu and Mh mixed infection was 20 .0% .The results of drug sensitive tests showed the drug resistances of Uu ,Uu＋ Mh ,Mh infections were different for 13 kinds of antibacterials .The Uu was most resistant to lincocin （98 .0% ） ,then ciprofloxacin （81 .2% ） and norflox‐acin （70 .6% ） .Drug resistance rates of Uu ＋ Mh to lincomycin ,ciprofloxacin ,norfloxacin ,azithromycin ,rox‐ithromycin ,clarithromycin ,and sparfloxacin were all over 70 .0% .CONCLUSION Mycoplasma infection in uro‐genital tract is mainly caused by Uu with a serious drug resistance ,and rational clinical medication should be used based on antimicrobial susceptibility test results .

关 键 词：泌尿生殖道 解脲脲支原体 人支原体 药敏试验 

分 类 号：R375[医药卫生—病原生物学]