肺炎衣原体感染对老年冠心病患者疾病进展影响的研究  

Study on effect of Chlamydia pneumoniae infection on progression of senile coronary heart disease

作　　者：周敏[1] 胥学伟[1] 杨兰菊[1] 康爱民[1] 刘树琴[1] 李义波[1] 

机构地区：[1]聊城市人民医院心内科,山东聊城252000

出　　处：《中华医院感染学杂志》2014年第23期5794-5796,共3页Chinese Journal of Nosocomiology

基　　金：山东省卫生厅重点规划基金项目(SW-2010B-021)

摘　　要：目的探讨肺炎衣原体感染对老年冠心病患者的影响因素,为临床治疗提供参考依据。方法选取2011年4月-2013年6月肺炎衣原体感染的老年冠心病患者81例和未合并肺炎衣原体感染的老年冠心病患者82例分别作为A、B两组,测定内皮素-1(ET-1)、白介素-6(IL-6)、C反应蛋白(CRP)、纤维蛋白原(Fg)、可溶性血管细胞黏附因子-1(sVCAM-1)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白Ⅰ(CTnⅠ)水平并进行比较,采用SPSS13.0进行统计分析;将A组患者均给予阿奇霉素口服,对该组患者治疗前后CP-IgA和IgG水平进行测定。结果 A组患者ET-1、IL-6、CRP、Fg、sVCAM-1、CK、CK-MB、CTnⅠ水平分别为(51.23±20.54)pg/ml、(10.61±12.46)ng/L、(1.54±2.72)mg/L、(2.98±0.84)g/L、(27.33±25.78)IU/L、(159.67±87.36)IU/L、(17.05±10.32)IU/L、(0.16±0.08)ng/ml均明显高于B组,两组比较,差异有统计学意义(P<0.05);经过治疗A组患者CP-IgA和IgG阳性率分别为32.10%、27.16%,治疗前的69.14%、53.09%明显降低,差异有统计学意义(P<0.05)。结论肺炎衣原体感染与老年冠心病有着密切的关系,病原体感染所致的炎症因子升高可促进动脉粥样硬化的病程进展,从而增加患者发生心梗等心血管事件的概率;通过阿奇霉素治疗,可以有效治疗肺炎衣原体感染,有利于稳定患者病情。OBJECTIVE To investigate the influencing factors of Chlamydia pneumoniae infection in elderly patients with coronary artery disease .METHODS Totally 81 patients with coronary heart disease who had C .pneumoniae infection and 82 patients with coronary heart disease which were not accompanied by C .pneumoniae infection were selected and set respectively as groups A and B .The two groups were measured for ET‐1 ,IL‐6 ,CRP ,Fg ,sV‐CAM‐1 ,CK ,CK‐MB ,CTnⅠ levels and compared with the software SPSS13 .0 .All patients in group A were treated with oral azithromycin ,CP‐IgA and IgG levels before and after treatment were determined for this group . RESULTS Levels of ET‐1 ,IL‐6 ,CRP ,Fg ,sVCAM‐1 ,CK ,CK‐MB ,CTnⅠ in group A （51 .23 ± 20 .54）pg/ml;（10 .61 ± 12 .46）ng/L ;（1 .54 ± 2 .72）mg/L ;（2 .98 ± 0 .84）g/L ;（27 .33 ± 25 .78）IU/L ;（159 .67 ± 87 .36）IU/L ;（17 .05 ± 10 .32）IU/L ;（0 .16 ± 0 .08）ng/ml were significantly higher than in group B （P〈0 .05） .After treat‐ment ,the positive rate for CP‐IgA and IgG were 32 .10% and 27 .16% in group A ,which were significantly lower than before treatment （69 .14% and 53 .09% ） （P〈0 .05） .CONCLUSION C .pneumoniae infection and coronary heart disease have a close relationship ,elevated inflammatory cytokines caused by pathogen infection may promote progression of atherosclerosis ,thereby increasing the probability of myocardial infarction and other cardiovascular events in patients .Azithromycin treatment can effectively reduce C .pneumoniae infection ,which helps to stabilize the patient＇s condition .

关 键 词：肺炎衣原体 感染 老年患者 冠心病 

分 类 号：R374[医药卫生—病原生物学]