人乳头状瘤病毒感染与乳腺癌发病相关性的临床研究  

Clinical research on HPV18,HPV16 infection associated with breast cancer

作　　者：任亚锋[1] 张博爱[2] 冯晓东[3] 刘黎明[4] 

机构地区：[1]郑州大学第一附属医院研究生处,河南郑州450052 [2]郑州大学第一附属医院神经内科,河南郑州450052 [3]河南中医学院第一附属医院康复中心,河南郑州450000 [4]河南省人民医院中医科,河南郑州450003

出　　处：《中华医院感染学杂志》2014年第23期5802-5803,5806,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(30872464)

摘　　要：目的研究人乳头状瘤病毒(human papilloma virus,HPV)18、16的感染与乳腺增生症和乳腺癌发病的相关性,探讨预防乳腺增生症和乳腺癌的方法。方法选取2012年1月-2013年6月医院就诊240例患者,分为乳腺癌(癌变组)和乳腺增生患者(增生组)各120例,取增生乳腺组织旁边的正常乳腺组织120份为正常对照组,运用原位杂交法分别测定HPV16、18的感染情况并记录,运用SPSS17.0进行统计分析。结果癌变乳腺组织HPV16、HPV18的感染率分别为51.67%、56.67%、48.33%,增生乳腺组织为31.67%、35.00%、15.00%,正常乳腺组织为11.67%、15.00%、6.67%,除了增生乳腺组织与正常乳腺组织的共感染外,其他数据进行组间比较,差异均有统计学意义(P<0.05)。结论 HPV16、18的共同感染与乳腺癌的发生有着密切的关系,但感染了HPV16、HPV18又不一定会诱发乳腺癌,乳腺癌的发病机制还需要做进一步的探讨。OBJECTIVE To study the correlation between the human papilloma virus （HPV）18 ,16 infections with the development of breast hyperplasia and breast cancer ,and to investigate the prevention of breast hyperplasia and breast cancer .METHODS During the period of Jan .2012 -Jun .2013 ,240 cases of patients with breast canc‐er and breast hyperplasia diagnosed in our hospital were selected ,and grouped into the breast cancer group and the breast hyperplasia group ,with 120 cases in each group .Using 120 samples of normal breast tissue next to the proliferative breast tissue as control ,in situ hybridization assay was used to determine HPV16 ,18 infections ,and the results were recorded and statistically analyzed using SPSS 17 .0 .RESULTS The HPV16 ,18 infection rates of cancerous breast tissue were 51 .67% ,56 .67% and 48 .33% ,while the rates for the proliferation of breast tissue and the normal breast tissue were 31 .67% ,35 .00% ,15 .00% and 11 .67% ,15 .00% ,6 .67% ,respectively . Except the co‐infection rate of proliferative breast tissue and normal breast tissue ,all other data were compared between groups ,and the differences were statistically significant （P〈0 .05） .CONCLUSION HPV16 ,18 co‐infec‐tion was closely correlated with the occurrence of breast cancer ,but infection with HPV16 ,18 did not necessarily cause breast cancer .The pathogenesis of breast cancer requires further exploration .

关 键 词：乳腺癌 乳腺增生 人乳头状瘤病毒 

分 类 号：R373[医药卫生—病原生物学]