延边地区胃癌中TP和COX-2表达及其临床意义  

Expression of TP and COX-2 in Gastric Cancer and Its Significance in Yanbian Region,Jilin Province

作　　者：全雄男[1] MEIHUA PIAO 胡早秀[3] 

机构地区：[1]延边大学附属医院,吉林延边133000 [2]Cheju Halla University,South Korea [3]云南省肿瘤医院,云南昆明650118

出　　处：《中国肿瘤》2014年第12期1034-1038,共5页China Cancer

摘　　要：[目的]探讨TP和COX-2在胃癌中的表达及其临床意义。[方法]采用免疫组化方法检测TP和COX-2在50例胃癌中的表达,分析其与胃癌临床病理特征及预后的关系。[结果]TP和COX-2在胃癌中的阳性表达率分别为56.0%(28/50)和62.0%(31/50)。TP蛋白表达与胃癌的分化程度、浸润深度和淋巴结转移相关(P<0.05);COX-2蛋白表达与胃癌淋巴结转移相关(P<0.05)。胃癌组织中TP和COX-2的表达呈正相关(χ2=4.565,P<0.05)。TP表达阳性和阴性者的5年生存率分别为25.0%和54.5%(P<0.05);COX-2表达阳性和阴性者的5年生存率分别为22.6%和63.2%(P<0.05)。[结论 ]TP和COX-2在胃癌的发生发展中可能起重要作用,可作为预测胃癌预后的指标。[Purpose] To investigate the expression of TP and COX-2 in gastric cancer and its clinical significance.[Methods] The expression of TP and COX-2 in 50 cases with gastric cancer was detected by immunohistochemistry method. The relationship of TP and COX-2 expression with the clinicopathological features and prognosis were analyzed.[Results] The positive rate of TP and COX-2 in gastric cancer was 56.0%（28/50） and 62.0%（31/50） respectively. The expression of TP in gastric cancer tissue related to differentiation,invasion and lymph node metastasis（P〈0.05）. The expression of COX-2 related to lymph node metastasis（P〈0.05）. Positive correlation was found between TP expression and COX-2 expression in gastric cancer tissues（χ^2=4.565,P〈0.05）. The 5 year survival in patients with positive and negative expressions of TP was 25.0% and 54.5%（P〈0.05）,and it in patients with positive and negative expression of COX-2 was 22.6% and 63.2%（P 0.05） respectively.[Conclusion] TP and COX-2 might play an important role in carcinogenesis and progress of gastric cancer. Expression of them can be used as prognostic markers for gastric cancer.

关 键 词：胃癌 胸苷磷酸化酶 环氧合酶-2 预后 

分 类 号：R651.15[医药卫生—外科学]