金荞麦总黄酮软胶囊的处方研究  

Prescription of Jinqiaomai Total Favonoids Soft Capsule

作　　者：董焱[1] 李巍[1] 生依灵[2] 张向荣[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《现代药物与临床》2014年第11期1231-1233,共3页Drugs & Clinic

摘　　要：目的优化金荞麦总黄酮软胶囊内容物的处方。方法以内容物沉降体积比、重新分散性为考察指标,通过对基质、助悬剂和润湿剂的筛选,确定金荞麦总黄酮软胶囊内容物的处方。结果以大豆油为稀释剂,金荞麦总黄酮粉末过120目筛,加大豆油用量为金荞麦总黄酮1.5倍,单硬脂酸甘油脂1%,司盘80为0.5%,所得金荞麦总黄酮软胶囊内容物混悬液最为稳定。结论所得处方合理,制得的金荞麦总黄酮软软胶囊外形分散均匀,软硬适中,装量差异符合规定。Objective To optimize the prescription of Jinqiaomai Total Favonoids Soft Capsule. Methods Diluent, suspending agent, and moistening agent were screened and sedimentation volume ratio and redispersion were used as indexes to obtain the optimized prescription of Jinqiaomai Total Favonoids Soft Capsule contents. Results Soybean oil was chosen as the diluent and total favonoids powder was passed through 120-mesh sieve. The prescription of Jinqiaomai Total Favonoids Soft Capsule containing soybean oil with 1.5 times amount of total flavonoids, 1% glyceryl monostearate as suspending agent, and 0.5% Span 80 as moistening agent showed the best stability. Conclusion The prescription is reasonable for Jinqiaomai Total Favonoids Soft Capsule with uniform dispersion, moderate hardness, and good content uniformity.

关 键 词：金荞麦总黄酮软胶囊 沉降体积比 重新分散性 处方 

分 类 号：R944[医药卫生—药剂学]