164例住院患者药物性肝损害临床分析  

Clinical Analysis of 164 Hospitalized Patients with Drug-Induced Liver Injury

作　　者：邓蓉蓉[1] 陈攀[1] 曹媛[1] 许晨舒[1] 陈杰[1] 

机构地区：[1]中山大学附属第一医院,广东广州510080

出　　处：《今日药学》2014年第11期813-815,共3页Pharmacy Today

摘　　要：目的 分析药物性肝损害（DILI）的致病药物和临床特点,为临床合理用药提供参考。方法 收集本院2013-01~12住院患者中发生药物性肝损害的病例,对患者的基础疾病、用药史、肝损害分型及预后进行回顾性分析。结果 共筛选到符合DILI诊断标准的患者164例,导致药物性肝损害的前五类药物分别是化疗药（51.98%）、中药（8.42%）、抗结核药（8.42%）、抗菌药（7.43%）和心血管系统用药（5.45%）;肝损害类型以肝细胞型为主,占71.34%,其次为胆汁淤积型（15.24%）和混合型（13.41%）;经过保肝治疗,19.51%的患者治愈,64.63%的患者好转,9.15%的患者无效,1.22%的患者死亡。结论 本院导致肝损害的药物以化疗药为主,多数为肝细胞型,经治疗后预后较好。Objective To investigate the drugs and clinical characteristics of 164 patients with drug-induced liver injury（DILl）. Methods A total of 164 patients with DILl were collected from January to December 2013 in the hospital. Their basic diseases, drug history, classification and prognosis were retrospectively analyzed. Results The top 5 drugs leading to liver damage were chemotherapy drug（Sl.98% ）, traditional Chinese medicine（ 8.42%）, anti-tuberculosis drug （8.42%） antimicrobials （7.43%）and cardiovascular drug （5.45%）.The majority type of DILI was hepatocellular type （71.34%）, followed by eholestasis type （15.24%）and mixed type （13.41%）. The cure rate was 19.51%, the improvement rate was 64.63%, the worsening rate was 9.15% and the mortality rate was 1.22%.Conclusion In the hospital, the drugs induced DILI mainly were chemotherapy drugs, and the mainly type of injury was hepatocellular injury type. The prognosis of DILI was relatively good after appropriate treatment.

关 键 词：药物性肝损害 预后 回顾性分析 

分 类 号：R97[医药卫生—药品]