青少年抑郁症患者脑白质的弥散张量成像研究  

Study of white matter in adolescent patients with depression by MR-diffusion tensor imaging

作　　者：毛宁[1] 王滨[1] 徐聪[1] 刘泉源[1] 王光彬[2] 

机构地区：[1]滨州医学院,264003 [2]山东省医学影像学研究所,济南市250021

出　　处：《实用医学杂志》2014年第23期3759-3762,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81171303)

摘　　要：目的:应用基于纤维束示踪的空间统计分析(tract-based spatial statistcs,TBSS)方法,探讨青少年抑郁症患者大脑白质的变化。方法:收集年龄、性别、教育程度匹配的35例首发青少年抑郁症患者(抑郁组)和40例健康青少年(对照组),并对其进行全脑的DTI扫描,应用TBSS的方法比较两组间各向异性分数(fractional anisotropy,FA)、轴向扩散率(axial diffusivity,AD)、径向扩散率(radial diffusivity,RD)和平均扩散率(mean diffusivity,MD)的差异。结果:抑郁组脑白质微结构异常,与对照组相比,胼胝体体部的FA值降低(P<0.01),RD、MD值升高(P<0.01),AD值无明显变化(P>0.05)。抑郁症组胼胝体体部FA值与抑郁严重程度呈负相关(P<0.01)。结论:脑白质异常参与青少年抑郁症的发生过程,这些改变发生在疾病发生过程的早期。Objective To investigate the changes of the white matter in adolescent depression by using the method of tract-based spatial statistics （TBSS）. Methods We employed TBSS to examine WM microstructure in 35 treatment-naive adolescents with clinical depression and in 40 matched controls. By using the TBSS, we compared the difference of fractional anisotropy （FA）, axial diffusivity （AD）, radial diffusivity （RD） and mean diffusivity （MD） between theadolescent patients with depression and the controls. Results Our analysis revealed the abnormal WM microstructures in the clinically depressed adolescents. The whole-brain analysis revealed that patients, with lower FA values in the body of the corpus callosum （CC） （P 〈 0.01）, had elevated RD and MD （P 〈 0.01）, and preserved AD （P 〉 0.05）. The FA values in the body of the corpus callosum was negatively correlated with the severity of depression （P 〈 0.01）. Conclusions Our findings suggest that WM abnormalities are involved in the path-physiology of depression. Importantly , our findings show that these WM abnormalities present early in the course of the disorder.

关 键 词：青少年抑郁症 扩散张量成像 白质 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]