不同剂量依托咪酯脂肪乳对全麻上腹部手术患者的影响  

Influence of Different Doses of Etomidate Fat Emulsion on General Anesthesia Patients Underwent Abdominal Operation

作　　者：王昌合 

机构地区：[1]淮北矿工总医院麻醉科,安徽省淮北市235000

出　　处：《临床合理用药杂志》2014年第33期11-12,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的：观察不同剂量依托咪酯脂肪乳对全麻上腹部手术患者的影响。方法选取2012年1月—2014年4月在我院行全麻上腹部手术并使用依托咪酯脂肪乳的患者60例，依据依托咪酯脂肪乳剂量分为小剂量组、中计量组、大剂量3组，每组20例。小剂量组依托咪酯脂肪乳剂量〈1.5mg/kg，中剂量组依托咪酯脂肪乳剂量为1.5-2.0mg/kg，大剂量组为依托咪酯脂肪乳剂量〉2.0mg/kg。比较3组患者用药后20min血流动力学指标、全麻维持时间、苏醒时间（呼吸恢复时间、睁眼时间、拔管时间、答题切问时间）、苏醒期躁动发生率。结果3组患者用药后20min血流动力学指标、维持时间、苏醒时间（呼吸恢复时间、睁眼时间、拔管时间、答题切问时间）、苏醒期躁动发生率比较，差异均有统计学意义（ P〈0.05）。结论不同剂量依托咪酯脂肪乳对全麻上腹部手术患者维持时间、苏醒时间、苏醒期躁动发生率影响明显，长时间手术中应尽可能采取一定的措施以减少苏醒期躁动等的发生。Objective To observe the influence of different doses of etomidate fat emulsion on general anesthesia pa-tients underwent abdominal operation. Methods A total of 60 general anesthesia patients underwent abdominal operation who used etomidate fat emulsion in our hospital from January 2012 to April 2014 were selected and divided into three groups：small dose group（etomidate fat emulsion dose〈1. 5mg/kg,n=20）,medium dose group（etomidate fat emulsiondose 1. 5-2. 0mg/kg,n=20）,high dose group（etomidate fat emulsion dose〉2. 0mg/kg）. Hemodynamic index,maintenance time,recovery time（ breathing recovery time,eye opening time,extubation time,right answer time）after treatment of 20 minutes and inci-dence of agitation were compared among the three groups. Results There were statistically significant differences of hemody-namic index,maintenance time,recovery time（ breathing recovery time,eye opening time,extubation time,right answer time）and incidence of agitation among the three groups（P〈0. 05）. Conclusion Different doses of etomidate fat emulsion have influence on maintenance time,recovery time and incidence of agitation in general anesthesia patients underwent abdominal operation,which should pay more attention to.

关 键 词：依托咪酯脂肪乳 麻醉 全身 剂量效应关系 药物 

分 类 号：R614[医药卫生—麻醉学]