消旋卡多曲联合蒙脱石散治疗儿童轮状病毒性肠炎的疗效研究  

Clinical Efficacy of Racecadotril Combined with Montmorillonite Powder in the Treatment of Children with Rotavirus Enteritis

作　　者：张瑜 张学俊 

机构地区：[1]江西省宜春市第五人民医院儿科,336000

出　　处：《临床合理用药杂志》2014年第33期13-14,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨消旋卡多曲联合蒙脱石散治疗儿童轮状病毒性肠炎的临床疗效。方法选取我院2013年2月—2014年2月收治的78例轮状病毒性肠炎患儿,随机分为对照组和观察组,各39例。对照组给予蒙脱石散治疗,观察组给予消旋卡多曲联合蒙脱石散治疗。比较两组患儿治疗总有效率,止吐、止泻、退热时间及住院时间和不良反应发生率。结果观察组患儿总有效率为94.9%(37/39),高于对照组的82.1%(32/39),差异有统计学意义(P<0.05);观察组患儿止吐、止泻、退热及住院时间均短于对照组(P<0.05)。两组患儿均未发生严重的不良反应。结论消旋卡多曲联合蒙脱石散治疗儿童轮状病毒性肠炎疗效确切,不良反应小。Objective To investigate the clinical efficacy of racecadotril combined with montmorillonite powder in the treatment of children with rotavirus enteritis. Methods A total of 78 children with rotavirus enteritis in our hospital were select-ed from February 2013 to February 2014,and they were randomly divided into control group and observation group,39 cases in each group. Control group was treated with montmorillonite powder,while observation group was treated with racecadotril com-bined with montmorillonite powder. The total effective rate,vomit-stopping time,diarrhea-stopping time,antifebrile time, hospitalization time and incidence of adverse reactions of the two groups were compared. Results The total effective rate of ob-servation group was 94. 9%（37/39）,was higher than that of control group of 82. 1%（32/39）（P〈0. 05）. The vomit-stopping time,diarrhea-stopping time,antifebrile time,hospitalization time of observation group were shorter than those of control group（P〈0. 05）. No one of the two groups occurred serious adverse reactions. Conclusion Racecadotril combined with montmorillonite powder has exact effect in the treatment of children with rotavirus enteritis,and with less adverse reactions.

关 键 词：肠炎 消旋卡多曲 蒙脱石散 轮状病毒感染 儿童 治疗结果 

分 类 号：R725.1[医药卫生—儿科]