流行性腮腺炎疫苗两剂次接种保护效果系统评价  

Meta-analysis on the protective effect of two-dose vaccination of mumps vaccine

作　　者：陈国翠[1] 刘卫民[1] 陈伟红[1] 

机构地区：[1]深圳市罗湖区疾病预防控制中心,广东深圳518020

出　　处：《中国预防医学杂志》2014年第7期689-692,共4页Chinese Preventive Medicine

摘　　要：目的综合评估腮腺炎二剂次接种和一剂次接种疫苗保护效力的差异,为制定更有效地控制流行性腮腺炎的免疫策略提供依据。方法以"流行性腮腺炎"、"mumps","Vaccine effectiveness"等为主题词检索中国生物医学文献光盘数据库、Pubmed、EMbase、Web of Science等数据库,并对所获文献进行质量评价、筛选和提取相关研究资料,并以SD值及95%可信区间为效应指标,利用Stata 10.0软件进行Meta分析。结果两次疫苗接种组的免疫保护效力显著高于单次接种组的免疫保护效力,标准化差值为[SMD=0.24,95%CI(0.03,0.44),P=0.023]。同时,采用敏感性分析对结果的可靠性和稳定性进行评价,检验的结果为各研究组之间无显著的异质性(χ2=9.21,P=0.162),说明结果具有一定的可靠性和稳定性。结论二剂次接种具有更好的疫苗保护效果,我国属于腮腺炎高发地区,二剂次接种策略适合在全国范围内推广应用。Objective To evaluate the protective effect of two-dose mumps vaccination by comparing with onedose vaccination, and to provide the scientific basis for immunization programs against mumps. Methods Literatures related to mumps vaccine were retrieved from Pubmed, EMbase, SCI Web of Science, CNKI and other databases. The software Stata （Version10.0） was used for meta-analysis. Results The protective effect of two-dose vaccination was higher compared to that of one dose （SMD=0.24, 95%CI： 0.03-0.44, P ：0. 023）. Meanwhile, a sensitivity analysis was performed by omitting one study at a time and calculating the pooled SMD for the remaining studies to assess the effects of each individual study on the pooled SMD. This sensitivity analysis demonstrated that none individual studies dramatically influenced the pooled SMD （χ2 = 9.21, P=0. 162） and the results of the meta-analysis were reliable and stable. Conclusions Compared with one-close mumps vaccination strategies applied in most parts of country, two-dose mumps vaccination has high- er effectiveness which should be promoted nationwide.

关 键 词：系统评价 腮腺炎疫苗 免疫效果 保护效果 

分 类 号：R186[医药卫生—流行病学]