不同年龄段男性血清总睾酮和游离睾酮水平分析  

Analysis of male serum total Testosterone and serum free Testosterone in different ages

作　　者：刘太华[1] 杨瑞峰[1,2] 孔祥斌[1] 陈耀平[1] 李红钢[1,2] 章慧平[1,2] 夏伟[1,2] 官黄涛[1,2] 谷翊群[3] 商学军[4] 周远忠[5] 吴伟雄 熊承良[1,2] 

机构地区：[1]华中科技大学同济医学院计划生育研究所/生殖医学中心,湖北武汉430030 [2]武汉同济生殖医学专科医院,湖北武汉430030 [3]国家人口计生委科学技术研究所,北京100081 [4]南京军区南京总医院男科,江苏南京210002 [5]遵义医学院公共卫生学院预防医学教研室,贵州遵义563000 [6]广州市人口和计划生育科研所,广东广州510410

出　　处：《中国计划生育和妇产科》2014年第9期16-18,共3页Chinese Journal of Family Planning & Gynecotokology

基　　金："十二五"国家科技支撑计划项目(项目编号:2012BAI32B03)

摘　　要：了解不同年龄段男性血清总睾酮（total testosterone,TT）和游离睾酮（calculated free testosterone,c FT）水平的变化。方法按不同年龄段将研究对象分为6个组。分别测定血清TT、性激素结合球蛋白（sex hormone binding globulin,SHBG）,计算出血清c FT,分析年龄与男性血清TT和c FT水平的关系。结果不同年龄组间血清TT水平60~〈70岁组与30~〈40岁、40~〈50岁组比较差异有统计学意义（P〈0.05）,其他各组间差异无统计学意义（P〉0.05）。血清c FT、SHBG水平除20~〈30岁、30~〈40岁两组间比较差异无统计学意义（P〉0.05）,其他各组间两两比较差异均有统计学意义（P〈0.05）。血清TT,SHBG与年龄呈正相关,而血清c FT与年龄呈负相关（P〈0.05）。结论随着年龄的增长,血清TT水平呈现微弱升高趋势,而血清c FT水平在40岁以后出现明显下降。作为中老年男性性腺功能低下诊断指标,血清c FT水平具有更好的敏感性。Objective To explore the variation of serum total testosterone（ TT） and calculated serum free testosterone（ c FT） in male of different ages. Methods The subjects were divided into six groups according to age groups. The level of TT and sex hormone binding globulin（ SHBG） were detected. Then serum c FT was calculated. The relationship between levels of serum TT,c FT and age were analyzed. Results The differences in level of TT between 60 ~ 〈 70 group and 30 ~ 〈 40 group,40 ~ 〈 50 group had statistical significance（ P 〈 0. 05）,no significant differences between other groups were found（ P 〉 0. 05）. The differences in level of c FT,SHBG between 20 ~ 〈 30 group and 30 ~ 〈 40 group had no statistical significance（ P 〉 0. 05）. The differences between other groups had statistical significance（ P 〈 0. 05）. TT and SHBG were positively correlated with age while c FT was negatively correlated with age（ P 〈 0. 05）. Conclusion The tendency of the level of TT increases slightly with ages,while the level of c FT has obviously declining trend in an adult 〉 40. As the diagnostic criteria of hypogonadism in the middle- aged and elderly male,the level of c FT has better sensitivity.

关 键 词：睾酮 游离睾酮 性激素结合球蛋白 

分 类 号：R699[医药卫生—泌尿科学]