盐酸莫西沙星离子-温度双敏感眼用原位凝胶的研制  

Preparation of Moxifloxacin Hydrochloride Ion-temperature Sensitive in situ Ophthalmic Gel

作　　者：徐颖[1] 张焱[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2014年第12期1143-1146,共4页Chinese Journal of Pharmaceuticals

摘　　要：以泊洛沙姆407和泊洛沙姆188为温度敏感基质材料,海藻酸钠和羟丙甲纤维素E50LV为离子敏感基质材料,制备盐酸莫西沙星离子-温度双敏感眼用原位凝胶。通过考察不同基质对成胶温度、成胶时间、黏度和体外释放行为的影响,得到优化处方组成为:海藻酸钠0.5%,羟丙甲纤维素0.3%,泊洛沙姆188 5.9%和泊洛沙姆407 17.7%。该制品在室温下为自由流动的液体,经人工泪液稀释后在33℃时能发生相变形成凝胶,在体外4 h时基本释放完全。The in situ gel loaded with moxifloxacin hydrochloride for ophthalmic use was prepared with Poloxamer 407 and Poloxamer 188 as temperature sensitive matrices and sodium alginate and hypromellose（HPMC）E50LV as ion sensitive matrices. The formulation was optimized with gelation temperature, gelation time, viscosity and drug release as indexes. The results showed that the optimal composition of the gel base was 0.5% of sodium alginate, 0.3% of HPMC E50 LV, 5.9% of Poloxamer 188 and 17.7% of Poloxamer 407. The product was freely flowing liquid at room temperature and it converted to a film gel at 33 ℃ after diluted by simulated tear fluid. The in vitro release of moxifloxacin hydrochloride from the in situ gel was completed within 4 h.

关 键 词：盐酸莫西沙星 离子-温度双敏感 眼用原位凝胶 

分 类 号：R944.9[医药卫生—药剂学]