血清降钙素原水平与脓毒血症预后的相关性研究  

Correlation of serum procalcitonin and prognosis of neonatal sepsis

作　　者：向光明[1] 高宝安[1] 

机构地区：[1]三峡大学第一临床医学院 宜昌市中心人民医院呼吸内科,湖北省宜昌443003

出　　处：《中国基层医药》2014年第23期3558-3560,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨血清降钙素原（PCT）水平检测在脓毒血症预后判断中的临床价值。方法选取113例感染患者为研究对象，根据是否伴有脓毒血症分为观察组（脓毒血症）和对照组（非脓毒血症）。于患者入院时抗生素治疗前抽取患者静脉血2 mL应用免疫发光法检测PCT水平。比较两组入院时及入院后PCT水平，分析其与患者病情变化及预后的关系。结果观察组PCT（11．03±6．21）ng／mL，显著高于对照组的[（0．81±1．61）ng／mL]（t＝8．507，P＜0．01）；脓毒血症死亡患者血清PCT水平随着时间推移明显上升（F＝5．061，P＜0．05）；无效患者血清PCT水平随病情加重而显著升高（F＝4．793，P＜0．05）；好转患者血清PCT水平随病情好转而降低（F＝6．009，P＜0．05）。且PCT＜10 ng／mL者病死率（14．89％）明显低于PCT≥10 ng／mL患者（72．22％）。结论 PCT对预测脓毒血症的预后具有重要的临床价值，值得临床推广和应用。Objective To explore the correlation of serum procalcitonin and prognosis of neonatal sepsis. Methods 113 cases of infection were selected as the objects of study,which were divided into the observation group （sepsis） and control group （non sepsis） according to the presence of sepsis.2mL venous blood was selected when patients were admitted to hospital before antibiotic treatment.The level of PCT was detected by immunoluminometric assay.PCT level at admission and after treatment were used to analyze the relationship between changes and the severity and prognosis of patients.Results PCT level of the observation group [（11.03 ±6.21）ng/mL] were higher than that of the control group [（0.81 ±1.61）ng/mL] （t=8.507,P〈0.01）,Sepsis and death in patients with serum PCT values increased significantly over time （F=5.061,P〈0.05）;invalid value of serum PCT in patients with disease exacerbation was significantly higher（F=4.793,P〈0.05）;improved serum PCT values in patients with the disease better reduced（F=6.009,P〈0.05）.While PCT〈14.86ng/mL mortality rate （14.89%） was significantly lower than the PCT≥14.86ng/mL mortality rate （72.22%）.Conclusion PCT shows important clinical efficacy in forcasting prognosis of neonatal sepsis.It is worthy of wider promotion and application.

关 键 词：降钙素原 脓毒血症 预后 相关性 

分 类 号：R459.7[医药卫生—急诊医学]