不同分期糖尿病视网膜病变患者的前房角形态观察研究  

Anterior chamber angle shape of patients with diabetic retinopathy at different stages

作　　者：吕全[1] 蔡奕琪[1] 刘轶[1] 

机构地区：[1]福建医科大学附属闽东医院眼科,中国福建省福安市355000

出　　处：《国际眼科杂志》2015年第1期152-154,共3页International Eye Science

摘　　要：目的:运用光学相干断层扫描(OCT)技术对不同分期糖尿病视网膜病变(diabetic retinopathy,DR)患者的前房角形态开展临床研究,为糖尿病视网膜病变患者提供一种更为准确、便捷的青光眼预防措施。方法:我院诊治DR患者613例,按不同分期分为增殖期DR组353例和背景期DR组260例,另选100例糖耐量异常患者作为对照组。采用OCT收集前房角相关参数,包括房角开放距离(AOD)、小梁网虹膜空间面积(TISA)、房角隐窝面积(ARA)、房角角度(ACA)和前房深度(ACD)。结果:对照组、增殖期DR组和背景期DR组患者的AOD500,AOD750,TISA500,TISA750,ARA500和ARA750均存在显著性差异(P<0.01),以增殖期DR组最小,AOD500,AOD750,TISA500,TISA750,ARA500和ARA750分别为0.60±0.22mm,0.78±0.39mm,0.22±0.12mm2,0.45±0.19mm2,0.29±0.18mm和0.46±0.15mm。对照组、增殖期DR组和背景期DR组患者的ACA500,ACA750,ACD500和ACD750均存在显著性差异(P<0.01),以增殖期DR组最小,ACA500,ACA750,ACD500和ACD750分别为30.29°±8.19°,21.20°±7.40°,2.32±0.23μm和2.52±0.16μm。ROC分析显示这些指标对判断青光眼发作风险有意义。结论:OCT检测前房角形态指标参数,可很好的反应糖尿病视网膜病变的参数变化,是一种检测糖尿病视网膜病变患者更为准确、便捷的青光眼预防措施。AIM： To observe the anterior chamber angle shape of patients with diabetic retinopathy（ DR） at different stages using OCT,and to explore a more sensitive and accurate glaucoma preventing measure.METHODS： A total of 613 cases of DR patients were divided into proliferation phase group（ 353 cases） and background phase group（ 260 cases）,another 100 cases of patients with only diabetes were selected as control group. OCT was used to detect the anterior chamber angle related parameters, including angle opening distance（ AOD）,trabecular- iris space area（ TISA）,angle recess area（ ARA）,anterior chamber depth（ ACD）and anterior chamber angle（ ACA）.RESULTS： There were significant difference among AOD500,AOD750,TISA500,TISA750,ARA500 and ARA750 of control group, proliferation phase group and background phase group（ P 〈 0. 01）. The proliferation phase group was the lowest,AOD500,AOD750,TISA500,TISA750,ARA500 and ARA750 were 0. 60 ± 0. 22 mm,0. 78 ±0. 39 mm,0. 22 ± 0. 12mm2,0. 45 ± 0. 19mm2,0. 29 ± 0.18 mm and 0. 46 ± 0. 15 mm, respectively. There were significant difference among ACA500, ACA750, ACD500 and ACD750 of control group,proliferation phase group and background phase group（ P 〈 0. 01）. The proliferation phase group was the lowest,ACA500,ACA750,ACD500 and ACD750 were 30. 29° ± 8. 19°,21. 20° ± 7. 40°,2. 32 ±0. 23μ m and 2. 52 ± 0. 16μ m,respectively. In addition,ROC results indicated that all these indices exert significant difference on evaluating the stage of DR.CONCLUSION： Anterior chamber angle shape detectedusing OCT can reflect the change of retinopathy. OCT is an accurate and simple technique for detecting DR staging.

关 键 词：分期 糖尿病视网膜病变 前房角 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]