红紫光治疗白癜风的疗效观察及对黑素细胞α－MSH分泌的影响  

Clinical Observation of Combination Therapy of Infrared Ray and Excimer Laser for Leucroderma and Its Influence on the Secretion of α-MSH in Melanocytes

作　　者：赵晓冬[1] 王明志[1] 杨海龙[1] 董何欣 张喜晶[1] 李昕[1] 

机构地区：[1]大庆市人民医院皮肤性病科,黑龙江大庆163316

出　　处：《中国伤残医学》2015年第1期10-12,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：观察红外线联合308nm准分子激光照射皮损局部治疗白癜风的疗效，并分析其对表皮黑素细胞内α－MSH的含量的影响。方法：随机选取我院皮肤科门诊2012年3月～2014年3月的稳定期白癜风患者60例，将全部患者平均分为3组，即对照组A、对照组B和实验组，每组患者有20例。对照组A单纯采用红外线照射治疗；对照组B单纯采用308nm准分子激光治疗；实验组采用红外线联合308 nm准分子激光治疗。3组患者均选取1处躯干部位的皮损，分别采用各自的治疗方案，皮损部位均每周照射2次，每月为1疗程，连续3个疗程后对临床效果进行评价，并分析对黑素细胞α－MSH分泌的影响。结果：对照组A和对照组B的总有效率为分别为45．0％和50．0％，实验组总有效率为70．0％，实验组与对照组A与对照组B相比总有效率差异显著，具有统计学意义，P＜0．05。实验组α－MSH含量与对照组A和对照组B相比，差异显著，P＜0．05；对照组A和对照组Bα－MSH含量相比差异无显著性，P＞0．05。结论：红外线联合308nm准分子激光可增加黑素细胞中α－MSH的分泌，促进黑素含量增加、局部色素沉着，从而提升白癜风治疗效果，疗效确切，安全可靠，提升了患者的生活质量，增加了社会效益和经济效益。Objective：To observe the clinical effect of the treatment of leucroderma impaired skin by infrared ray combined with 308 nm excimer laser, and to analyze its influence on the amount ofα-MSH in epidermal melanocytes.Mehtods：Sixty leucroderma patients at stable phase in treatment in dermatology department of our hospital between February, 2012 and March, 2014 were randomly selected as participants, and were divided into three groups, namely, control group A, control group B and treatment group, with 20 patients in each group.For patients in control group A, infrared radiation therapy was adopted;for patients in control group B, 308nm excimer laser thera-py was adopted;for patients in treatment group A, therapy of infrared ray combined with 308nm excimer laser was adopted.For patients in each group, an impaired part of trunk skin was treated with respective therapy, twice a week, one month a treatment course.The clini-cal effects were evaluated and the influence ofα-MSH secretion in melanocytes was analyzed after three successive treatment courses.Re-sults：The total effective rates of control group A and control group B was respectively 45.0%and 50.0%, and that of the treatment group was 70.0%.The differences between treatment group and control groups A and B were statistically significant, with P〈0.05;the differ-ences in the amount ofα-MSH between treatment group and control groups A and B were statistically significant, with P〈0.05; the difference in the amount ofα-MSH between control group A and control group B was statistically insignificant, with P〉0.05.Conclu-sion：The combination therapy of infrared ray and 308nm excimer laser can increase the secretion ofα-MSH in melanocytes in leucroder-ma patients, and spur the content of melanine, local skin pigmentation, and thus promote the treatment effects of leucroderma, which is definite, safe, and sure.Therefore, this therapy can promote the living quality of patients and increase social and economic benefits.

关 键 词：白癜风 红外线照射 308nm准分子激光治疗 红紫光治疗 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]