医院感染鲍氏不动杆菌的临床特点及耐药分析  

Clinical characteristics and drug resistance of Acinetobacter baumannii in hospital infection

作　　者：张颖[1] 王仙园[2] 周娟[2] 于庆华[1] 

机构地区：[1]武警北京总队医院感染科,北京100027 [2]第三军医大学护理学院,重庆400038

出　　处：《中华医院感染学杂志》2014年第24期5999-6000,6020,共3页Chinese Journal of Nosocomiology

基　　金：全军"十一五"计划专项基金资助项目(06Z078)

摘　　要：目的了解医院鲍氏不动杆菌的临床特点及耐药性,为控制医院感染提供参考依据。方法回顾性分析医院2011-2012年299例医院感染患者临床资料,分析鲍氏不动杆菌的临床特点及耐药性,数据采用SPSS10.0进行统计处理。结果 2011、2012年鲍氏不动杆菌感染分别为3、18例,感染率分别为1.97%、12.24%,差异有统计学意义(P<0.01);21株鲍氏不动杆菌均来自痰培养标本,呼吸道为首发感染部位;21株鲍氏不动杆菌对头孢唑林、头孢呋辛、氨曲南、头孢哌酮、头孢曲松、头孢他啶、哌拉西林、诺氟沙星、庆大霉素、阿米卡星、妥布霉素、氨苄西林、氯霉素、环丙沙星抗菌药物均耐药,对亚胺培南敏感。结论鲍氏不动杆菌已成为医院感染的主要病原菌,且呈现逐年增加的趋势;临床护理人员应根据细菌特点加强预防控制措施。OBJECTIVE To investigate clinical characteristics and drug resistance of Acinetobacter baumannii in our hospital and to provide the basis for controlling hospital infection .METHODS A retrospective analysis was applied to the clinical data of 229 patients with hospital infection from 2011 to 2012 .The clinical characteristics and drug resistance of Acinetobacter baumannii strains in hospital infection were analyzed .The software SPSS10 .0 was used for statistical analysis .RESULTS There were 3 strains in 2011 and 18 strains in 2012 ,the hospital infection rates were 1 .97% and 12 .24% respectively .The difference was significant（P＆lt;0 .01） .Totally 21 A .baumannii strains were all from sputum specimens and respiratory tract was the first infection site .The 21 A .baumannii strains in hospital infection were resistant to antibiotics such as cefazolin ,cefuroxime ,aztreonam ,cefoperazone , ceftriaxone ,ceftazidime ,piperacillin ,norfloxacin ,gentamicin ,amikacin ,tobramycin ,ampicillin ,chlorampheni‐col ,and ciprofloxacin but sensitive to imipenem .CONCLUSION A .baumannii is the major pathogenic bacteria in hospital infection and shows an increasing trend year by year .Clinical nursing staff should strengthen the preven‐tion and control measures according to bacteriological characteristics .

关 键 词：鲍氏不动杆菌 医院感染 临床特点 耐药性 

分 类 号：R378[医药卫生—病原生物学]