高危型人乳头状瘤病毒感染宫颈的病原学研究  

Etiological analysis of high-risk cervical human papilloma virus infection

作　　者：魏琳琳[1] 杨波[1] 赵欣[1] 

机构地区：[1]辽宁医学院附属第一医院妇产科,辽宁锦州121000

出　　处：《中华医院感染学杂志》2014年第24期6079-6081,共3页Chinese Journal of Nosocomiology

基　　金：辽宁省卫生厅计划基金资助项目(LW-2010B029)

摘　　要：目的探讨宫颈持续性高危型人乳头状瘤病毒(HPV)在不同宫颈病变患者的感染状况、基因型分布及干预对策,为临床诊断预防治疗提供依据。方法采用导流杂交技术检测2010年4月-2013年6月在妇产科接受诊治的148例不同宫颈病变患者高危基因型,并制定相关的干预措施,数据采用SPSS13.0软件进行统计分析。结果 148例宫颈病变患者中发生高危型HPV感染106例,感染率71.62%;106例高危型HPV感染患者宫颈分泌物中检出9种高危型HPV,主要包括HPV-16、HPV-18、HPV-33、HPV-52、HPV-58,其中HPV-16最为常见,检出率为44.34%;106例高危型HPV感染患者单一感染75例占70.75%,多重感染31例占29.25%,多重感染所占比例随着宫颈病变级别的上升而呈现上升趋势。结论 HPV-16是最常见的高危型HPV感染基因型,致使宫颈癌变的主要原因是高危型HPV多重感染与持续性感染。OBJECTIVE To investigate the status ,genotype distribution and intervention measures of persistent high‐risk cervical human papilloma virus （HPV） infection in different patients with cervical lesions ,so as to provide the basis for clinical prevention ,diagnosis and treatment .METHODS The flow‐through hybridization technique was used to detect high‐risk genotypes in 148 cases of different cervical lesions in patients who received treatment in the department of obstetrics and gynecology during Apr . 2010 - Jun . 2013 , and the relevant interventions were formulated .Data were statistically analyzed with the software SPSS 13 .0 .RESULTS Among the 148 patients of different ages with cervical lesions ,106 cases of high‐risk HPV were detected ,accounting for 71 .62% .From the cervical secretions of the 106 cases of high‐risk HPV infection ,nine kinds of high‐risk HPV were detected ,including HPV‐16 ,HPV‐18 ,HPV‐33 ,HPV‐52 ,and HPV‐58 ,among which HPV‐16 was the most common with a detection rate of 44 .34% .There were 75 cases of single HPV infection accounting for 70 .75% and 31 cases of multiple HPV infection accounting for 29 .25% . The proportion of multiple HPV infection showed an increasing trend along with the increase of the grade of cervical lesion .CONCLUSION HPV‐16 is the most common high‐risk HPV genotype ,cervical carcinogenesis is mainly due to multiple high‐risk HPV infection and persistent infection .

关 键 词：高危型人乳头状瘤病毒 宫颈病变 感染 基因型 干预对策 

分 类 号：R373[医药卫生—病原生物学]