替考拉宁治疗肝硬化患者肠球菌属感染致自发性腹膜炎的临床效果研究  

Clinical effect of teicoplanin on treatment of liver cirrhosis patients with spontaneous bacterial peritonitis induced by Enterococci infection

作　　者：张龙琪[1] 钟剑锋[1] 张春[1] 王伟洪[1] 

机构地区：[1]湖州市中心医院感染科,浙江湖州313000

出　　处：《中华医院感染学杂志》2014年第24期6089-6090,共2页Chinese Journal of Nosocomiology

基　　金：浙江省重大科技专项基金资助项目(2008C1309-1)

摘　　要：目的：调查替考拉宁治疗肝硬化患者肠球菌属感染致自发性腹膜炎患者的临床疗效和安全性，为临床治疗提供参考依据。方法回顾性分析2008年1月－2014年1月医院收治的73例肝硬化肠球菌属感染致自发性腹膜炎患者临床资料，均应用国产替考拉宁治疗，疗程7～14 d ，观察其临床、细菌学疗效以及不良反应发生率。结果73例肝硬化肠球菌属感染致自发性腹膜炎患者临床表现均有不同程度的发热、腹胀、腹围增加、尿少等；经替考拉宁治疗后，治愈39例，治愈率53．4％，显效25例，显效率34．2％，有效8例，有效率11．0％，无效1例，无效率1．4％，总有效率98．6％；73例患者无1例出现与治疗相关的不良反应。结论肝硬化肠球菌属感染致自发性腹膜炎时应用替考拉宁临床效果佳、安全性好，值得在临床推广使用。OBJECTIVE To investigate the clinical efficacy and safety of teicoplanin in treatment of liver cirrhosis patients with spontaneous peritonitis induced by Enterococci infection so as to provide guidance for clinical treat‐ment .METHODS The clinical data of 73 liver cirrhosis patients with spontaneous peritonitis induced by Enterococ‐ci infection who were treated in the hospital from Jan 2008 to Jan 2014 were retrospectively analyzed ,all the patients were treated with domestic teicoplanin ,with the treatment course raging between 7 and 14 days;the clini‐cal ,bacteriologic efficacy and the incidence of adverse reactions were observed .RESULTS The clinical manifesta‐tions of the 73 liver cirrhosis patients with spontaneous peritonitis induced by Enterococci infection included the va‐rying degree of fever ,abdominal distension ,increase of abdominal girth ,and oliguria .After the treatment with teicoplanin ,39 cases were cured with the cure rate of 53 .4% ,25 cases were markedly effective with the remarka‐ble effective rate of 34 .2% ,8 cases were effective with the effective rate of 11 .0% ,1 case was ineffective with the ineffective rate of 1 .4% ,and the total effective rate was 98 .6% .The treatment‐related adverse reactions did not occur in any of the 73 patients .CONCLUSION The use of teicoplanin can achieve significant clinical effect on treat‐ment of the liver cirrhosis patients with spontaneous peritonitis induced by Enterococci infection ,it is safe and worthy to be promoted in the hospital .

关 键 词：替考拉宁 肠球菌属 肝硬化 自发性腹膜炎 

分 类 号：R978.1[医药卫生—药品]