干燥综合征患者EB病毒感染分析  

Analysis of the situation of EB virus infection in patients with Sjogren′s syndrome

作　　者：李华[1] 王吉波[1] 王丽芹[1] 

机构地区：[1]青岛大学医学院附属医院风湿免疫科,山东青岛266003

出　　处：《中华医院感染学杂志》2014年第24期6154-6155,6176,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(30971586)

摘　　要：目的分析干燥综合征患者EB病毒感染状况,研究干燥综合征发病与EB病毒感染之间的相关性,为干燥综合征的诊断和治疗提供依据。方法选取干燥综合征患者75例、健康人员74名,取其血清进行ELISA和实时定量PCR检测,分析干燥综合征与EB病毒感染的相关性,采用SPSS13.0进行统计分析。结果 VCA-IgM抗体阳性率患者组为18.7%、对照组为2.7%,两组比较,差异有统计学意义(P<0.05);VCA-IgG抗体阳性率患者组为100.0%、对照组为97.3%,两组比较,差异无统计学意义;EA-IgG抗体阳性率患者组为60.0%、对照组为5.4%,两组比较,差异有统计学意义(P<0.05),患者组EB病毒DNA拷贝数均值明显高于对照组,差异均有统计学意义(P<0.05)。结论干燥综合征的发病与EB病毒的感染相关,给干燥综合征的诊断和治疗提供指导意义。OBJECTIVE To analyze the situation of EB virus infection in patients with Sjogren′s syndrome ,investi‐gate the relevancy between Sjogren′s syndrome and EB virus ,so as to provide some evidences for diagnosis and treatment of patients with Sjogren′s syndrome .METHODS Totally 75 cases of patients with Sjogren′s syndrome and 74 controlled cases were chosen .Blood serum was isolated ,and ELISA and RT‐PCR were used to analyze the relevancy between Sjogren′s syndrome and EB virus . SPSS13 .0 was adopted to make a statistic analysis . RESULTS The positive rate of VCA‐IgM antibody for the patients group （18 .7% ） was significantly higher than that of the control group （2 .7% ） .The comparison has statistical significance （P＆lt; 0 .05） .The positive rate of VCA‐IgG antibody for the patients group （100 .0% ） was a little higher than that of the control group （97 .3% ） , which is without statistical significance .The positive rate of EA‐IgG antibody for the patients group （60 .0% ） was significanfly higher than that of the control group （5 .4% ） （P＆lt;0 .05） .The average DNA copies of EB virus for the patients group was significantly higher than that of the control group （P＆lt; 0 .05） .CONCLUSION Sjogren′s syndrome is related with EB virus infection ,and it can guide the diagnosis and treatment of patients with Sjogren′s syndrome .

关 键 词：干燥综合征 EB病毒 感染 

分 类 号：R181.32[医药卫生—流行病学]