β2肾上腺素受体激动剂在急性呼吸窘迫综合征中的应用  

Beta-2 adrenergic receptor agonists and acute respiratory distress syndrome

作　　者：张琪[1] 

机构地区：[1]首都儿科研究所重症医学科,北京100020

出　　处：《中国小儿急救医学》2014年第12期752-755,共4页Chinese Pediatric Emergency Medicine

摘　　要：急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）是危及生命的严重疾病,病情凶险,病死率高.近年来,保护性机械通气策略和保守液体管理技术是ARDS有效的治疗手段,尚缺乏有效的药物治疗.近年来,基础研究显示,β2肾上腺素受体激动剂具有抑制肺部炎症反应、保护肺泡-微血管屏障、刺激肺表面活性物质分泌、促进肺水肿液清除等功能及肺损伤后的防御与修复等作用.本文就β2肾上腺素受体激动剂应用于ARDS的治疗研究进行归纳总结.Acute respiratory distress syndrome is a serious disease and has a high mortality rate.Protective ventilation strategy and conservative fluid management is the mainstay of treatment and there is no effective pharmacological treatment yet.Recent studies found that beta-2 adrenergic receptor agonists in the treatment of acute respiratory distress syndrome could inhibit the inflammatory response,protect the functions of alveolar capillary barrier,improve pulmonary edema fluid removal,promote the secretion of surfactant and enhance the impaired lung repair,and so on.This review aimed for the pathogenesis,mechanism of action and treatment mechanism of the recent studies.

关 键 词：Β2肾上腺素受体激动剂 急性呼吸窘迫综合征 

分 类 号：R563.8[医药卫生—呼吸系统]