肿瘤化疗病人畸变产物耳声发射的检测  

Detection of distortion-product ot oacoustic emissions in tumor chotherapy patientes

作　　者：朱永贤[1] 蒋华[1] 马文霞[1] 韩世洋[1] 

机构地区：[1]连云港市第二人民医院,江苏连云港222023

出　　处：《井冈山医专学报》2002年第4期7-8,共2页Journal of Jinggangshan Medical College

摘　　要：目的了解畸变产物耳声发射(DPOAE)在监测中毒性耳聋(化疗药物)方面的应用价值。方法检测80例(144耳)肿瘤化疗病人DPOAE的幅值和引出率。结果肿瘤病人DPOAE的幅值和引出率均较对照组明显下降,随着疗程的增加,DPOAE的引出率逐渐下降;纯音听阈值正常的肿瘤化疗病人与正常人相比,DPOAE的幅值及引出率亦明显降低。结论DPOAE能较好地反映肿瘤化疗病人的耳蜗功能情况,且较纯音测听更敏感、客观。Obj ec tive:To understand the value of using distortion product of otoacoustic emssion s(DPOAE)in monitoring o-totxicity hearing-loss.Methods:The amplitude and t he positive rates of DPOAE were detected in 80tumor chemotherapy patients(1 44ears).Results:The amplitude and the positive rates of DPOAE declined sign ificantly in o totoxicity groups against con-trol.With the increase of stage t he p ositive rates DPOAE decrease.The DPOAE amplitudes and the positive rate s of ototoxicity group with normal pure tome threshold were obvious lower than tha t in cont rols.Conclusion:The DPOAE can reflect the cochea' s function of tumo r chemotherapy patients.Contrast with pure tone audio mentry,DPOAE was more se nsitive and more ob-jective.

关 键 词：畸变产物耳声发射 检测 中毒性听力损失 纯音听阈 化疗药物 

分 类 号：R979.1[医药卫生—药品] R764.43[医药卫生—药学]