某院流感嗜血杆菌临床分布特点及其耐药性分析  

Haemophilus influenzae clinical distribution characteristics and drug resistance analysis in a hospital

作　　者：唐仕萍[1] 罗宇鹏[2] 卢先雷[2] 张婷[2] 

机构地区：[1]四川省成都市第五人民医院检验科,61113O [2]四川省简阳市中医院检验科,641400

出　　处：《检验医学与临床》2014年第A02期163-165,共3页Laboratory Medicine and Clinic

摘　　要：目的了解该院流感嗜血杆菌临床分布特点及其耐药性，为临床医生合理利用抗菌药物提供依据。方法收集该院2012年全年流感嗜血杆菌共132株资料，利用WHONET5．6统计软件进行统计分析。结果在所收集的132株流感嗜血杆菌资料中，产β-内酰胺酶64株，产酶率48.5％；耐药性分析显示：2012年全年该院临床分离出的132株Hin对四环素耐药率最高，达81.1％，其次复方新诺明71.9％，氨苄西林48.5％，而对头孢曲松、亚胺培南、环丙沙星、阿奇霉素仍具有很好的敏感性，无1例耐药。结论头孢第2代、第3代、第2代喹诺酮类、大环内酯类、碳青霉烯类，可作为临床经验治疗的首选药；而四环素、磺胺类抑菌活性稍差（耐药率大于或接近50％），说明此类药物不适宜作为临床经验治疗。Objective Understand the hospital clinical distribution characteristics and drug resistance of hae- mophilus influenzae , provide the basis for clinicians to reasonable use of antibiotics. Methods 132 strains of hae- mophilus influenzae data were collected in 2012 ,the data were analysised by WHONETS. 6 statistical software . Re- sults 64 strains of beta lactamase haemophilus influenzae was found in those 132 strains （48.48%） ,and Tetracy- cline resistant rate is highest, at 81.06%, followed by new Ming 71.96%, compound ampicillin 48. 48%, and for ceftriaxone,imine south, ciprofloxacin and azithromycin still has the very good sensitivity, no drug resistance in thosestrainsConclusion The second generation, third-- generation cephalosporin, second generation quinolone, large ring lactone class, carbon penicillium alkene, can be used as preferred drug for clinical treatment; but the bacteriostatic of tetracycline,and sulfa is a bit poor（the rate of resistance are greater than or close to 50%）it showed that such drugs is not suitable for clinical treatment.

关 键 词：流感嗜血杆菌 临床分布 8-内酰胺酶 耐药性分析 

分 类 号：R378.41[医药卫生—病原生物学]