儿童EB病毒感染与传染性单核细胞增多症  

Infectious Mononucleosis Associated with Epstein-Barr Virus Infection in Children

作　　者：张欣[1] 杜琼[1] 

机构地区：[1]四川省医学科学院/四川省人民医院,四川成都610072

出　　处：《检验医学与临床》2014年第A02期212-214,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨儿童EB病毒（EBV）感染与传染性单核细胞增多症（IM）的临床特征。方法收集四川省人民医院2012年1月至2013年12月符合EBV感染IM诊断标准的住院患儿83例。按年龄分为小于1岁组、1～3岁组、3～7岁组和7～14岁组。比较4组患儿的临床症状、体征、实验室检查和并发症的发生率。结果83例患儿中男57例，女26例。发热、颈淋巴大和扁桃体炎是IM患儿的主要临床表现，其阳性率分别是83.33％、41.18％和80.00％。肝大、脾大的发生率分别为18.63％和21.57％。4组常见的并发症主要有肺炎、肝损害、心肌损害、血小板减少和中性粒细胞减少，其中3～7岁组发生肝损害的概率高于其他几组。结论不同年龄段儿童EBV感染IM的临床症状、实验室检查及并发症存在差异。学龄前儿童肝脾大的发生率较高，WBC计数较高；3～7岁儿童肝酶升高的程度更重，肝损害的发生率更高。Objective To explore the clinical characteristics of infectious mononucleosis（IM） associated with Epstein-Barr virus（EBV） infection in children. Methods 83 children in the hospital with EBV-IM were collected from Jan 2012 to Dec 2013 in Sichuan Provincial Peoplers Hospital. All patients were divided into 4 groups as 〈1 years old group,l-3 years old group,3-7 years old group and 7-14 years old group. The clinical symptoms, signs, laboratory examinations and the incidence of complications between 4 groups were collected and compared. ResultsIn the 83 patients,57 were boys and 26 were girls. Fever,lymphadenopathy and pharyngitis were main manifestations of the children with IM,their incidence were 83.33% ,41.18% and 80.00%respectively. Incidence of splenomegaly, hepatomegaly were 18.63% and 21.57% respectively. The common complications of 4 group were pneumonia,hepat- ic lesion, myocardial damage, thrombocytopenia and neutrocytopenia. The incidence of hepatic lesion in group 3-7 year-old was higher than other group. Conclusion Clinical symptoms, signs, laboratory examinations and complica- tions of patients with IM varied in different age groups. The preschool children usually had high incidence of hepato- splenomegaly, higher liver enzyme and hepatic lesion.

关 键 词：EB病毒 传染性单核细胞增多症 儿童 

分 类 号：R512.7[医药卫生—内科学]