复方黄芪丹参颗粒剂治疗心绞痛临床和实验研究  

Clinical and Experimental Research of Compound Huangqi Danshen Granule on Treating Angina Pectoris

作　　者：张伯礼[1] 苏雅[2] 高秀梅[1] 董志立 徐宗佩[1] 王晓晖[1] 

机构地区：[1]天津中医学院,天津300193 [2]天津药物研究院,天津300193 [3]天津医药总公司,天津300150

出　　处：《天津中医》2002年第4期12-15,共4页Tianjin Journal of Traditional Chinese Medicine

摘　　要：目的 :探讨复方黄芪丹参颗粒剂对冠心病心绞痛临床和药效学影响。方法 :将246例心绞痛患者按2∶1比例 ,随机分为实验组和对照组 ,分别服用复方黄芪丹参颗粒剂和复方丹参片 ,4周为1个疗程 ,评定心电图、心绞痛疗效及硝酸甘油停减率。选Wistar雄性大鼠27只 ,随机分为对照组、复方黄芪丹参三七浸膏粉200mg/kg组及400mg/kg组 ,在行冠状动脉结扎术前1h灌胃给药 ,观察心电图ST段抬高幅度及心肌梗死面积。结果 :复方黄芪丹参颗粒剂在临床显效率 ,心绞痛次数 ,持续时间及心电图改善方面优于对照组 ,有显著差异 (P<0.05或P<0.01) ;灌胃复方黄芪丹参三七浸膏大鼠 ,急性心肌梗死时 ,各时间点ST段mV值均低于对照组 ,心肌梗死面积较对照组小 ,有显著差异 (P<0.05或P<0.01) ,且以400mg/kg组效果更为明显。结论 :复方黄芪丹参颗粒剂有保护心肌梗死所致心肌损伤的作用 ,能够明显改善心绞痛症状 ,对于气虚血瘀所致心绞痛疗效显著。Objective: To study the clinical and pharmacodynamic influence of Compound Huangqi Danshen Granule (CHDG) on angina pectoris. Methods: 246 cases were divided into two groups: control group (n=82) and treatment group (n=164) randomly taking Compound Danshen Tablet (CDT) and CHDG separately. Each course had 4 weeks. The improvement of the ECG and symptoms and the reducing need of the tablets served as evaluated indices. In experiments, 27 male wistar rats were randomly divided into three groups: control group, CHDG at 200 mg/kg group and CHDG at 400mg/kg group. Medicines were administrated an hour coronary artery ligation. The elevation of ST_segment and the area of myocardial infarction were observed. Results:The clinical effective rate, incidence and duration of angina and ECG change were superior in treatment group to those in control group. There was a significant difference (P<0.05, P<0.01). The mV value of ST_segment at different time points in treatment group were lower than in control group, and the area of myocardial infarction was less too (P<0.05, P<0.01).CHDG at 400 mg/kg group had a more obvious effect than theother treatment group. Conclusion: CHDG has a protective effect against injury of myocardial muscles due to myocardial infarction and notably improves the symptoms of angina pectoris, resulted from qi deficiency and blood stasis.

关 键 词：复方黄芪丹参颗粒剂 冠心病 心绞痛 临床研究 实验研究 治疗 

分 类 号：R259.414[医药卫生—中西医结合]