Cu(OAc)_2·H_2O/Dppp催化合成3-羰基-3-磺酰胺基丙酸酯  

Synthesis of 3-Oxo-3-sulfonamido Propionic Acid Ester Catalyzed by Cu( OAc)_2/ Dppp

作　　者：赵宙兴[1] 

机构地区：[1]青海大学化工学院,青海西宁810016

出　　处：《化学试剂》2014年第12期1130-1132,共3页Chemical Reagents

基　　金：2011年度中国科学院"西部之光"人才培养计划资助项目

摘　　要：以磺酰基叠氮、丙炔酸酯为原料,在Cu（OAc）2·H2O/Dppp催化下合成了标题化合物。产物结构经IR、1HNMR、13CNMR及元素分析证实。优化反应条件为：投料物质的量比n（磺酰基叠氮）∶n（丙炔酸酯）=1∶1.2,THF为溶剂,室温下反应10 min,总收率78%~90%,同时给出了可能的反应机理。该法具有反应时间短、收率高、操作简单、后处理方便的优点。A series 3-oxo-3-sulfonamido propionic acid esters were synthesized by the reaction of sulfonyl azide and propiolic acid ester using Cu（ OAc）2·H2O / Dppp as catalyst. The structures of all compounds were confirmed by IR,1HNMR,13 CNMR and elemental analysis. The optimal reaction conditions were as follow： ratio of sulfonyl azide to propiolic acid ester 1 ∶ 1. 2,THF as sovent,10 min of reaction time under room temperature. In addition,the probable mechanism for the reaction was proposed. This method had the advantages of short reaction time,high yields,simple work-up and easy postprocessing.

关 键 词：磺酰基叠氮 丙炔酸酯 CU AAC 合成 

分 类 号：O623.736[理学—有机化学]