嘧菌酯的新合成工艺研究  

Preparation of Azoxystrobin

作　　者：林富荣[1] 李伟冬[1] 颉林[1] 

机构地区：[1]常州大学江苏精细石油化工重点实验室,江苏常州213164

出　　处：《化学试剂》2014年第12期1147-1149,1152,共4页Chemical Reagents

基　　金：江苏省优势学科的资助项目

摘　　要：以邻氯苯乙酸为原料,先与氢氧化钠反应生成双钠盐,双钠盐与4,6-二氯嘧啶反应合成2-[2-(6-氯嘧啶-4-基氧)苯基]乙酸钠单钠盐。单钠盐酸化后与甲醇发生酯化反应生成2-[2-(6-氯嘧啶-4-基氧)苯基]乙酸甲酯,之后与原甲酸三甲酯反应生成E-2-[2-(6-嘧啶-4-基氧)-3-甲氧基]丙烯酸甲酯,再与水杨腈反应生成标题化合物。该路线与目前工业化普遍采取的路线相比,反应步骤少,而且废水大大减少。中间体和产品用核磁进行了表征。Azoxystrobin was prepared using o-chloro phenylacetic acid as raw material. 2-（ 2-（（ 6-chloropyrimidin-4-yl）oxy） phenyl） acetate which was prepared from o-chloro phenylacetic acid by hydrolysis with sodium hydroxide,coupling reaction with 4,6-dichloropyrimidine and ester reaction with methanol reacted with trmiethyl orthoformate to produce（ E）-methyl 2-（ 2-（（ 6-chloropyrimidin-4-yl） oxy） phenyl）-3-methoxyacrylate which reacted with 2-hydroxy-benzonitril to form the target product methyl（ E）-2-{ 2-[6-（ 2-cyanophenoxy）pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate. Compared withthe current industral way,the reaction steps is short and waste water is greatly reduced. The intermediates and product were confirmed by NMR.

关 键 词：嘧菌酯 邻氯苯乙酸 4 6-二氯嘧啶 水杨腈 

分 类 号：O626[理学—有机化学]