总有机碳分析法测定盐酸普鲁卡因注射液的含量  

Content Determination of Procaine Hydrochloride Injection via Total Organic Carbon

作　　者：杨松[1] 邓晓梅 赵文军[1] 王锦[1] 

机构地区：[1]沈阳军区联勤部药品仪器检验所,辽宁沈阳110026 [2]沈阳辉山卫生服务中心,辽宁沈阳110000

出　　处：《解放军药学学报》2014年第5期396-397,共2页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的建立一种盐酸普鲁卡因注射液含量的测定方法。方法使用总有机碳测定仪测定盐酸普鲁卡因注射液的含量,并与HPLC法测得的结果进行比较,验证总有机碳分析法测定盐酸普鲁卡因注射液含量的可行性。结果盐酸普鲁卡因在0.1~2.0μg·ml^-1浓度范围内线性关系良好。平均回收率为99.5%,RSD为1.5%（n=6）。总有机碳分析法和HPLC法测得的含量结果一致。结论总有机碳分析法操作简单、快速、准确,适用于盐酸普鲁卡因注射液含量的测定。Objective To establish a method for assessing the concentration of procaine hydrochloride injec- tion. Methods The concentration of procaine hydrochloride injection was measured by total organic carbon （ TOC ） and the result was compared with HPLC method. Results The linear range of procaine hydrochloride was 0.1 - 2.0 μg -ml^-1. The average recovery （ n =6） was 99.5% ,while RSD was 1.5% （ n =6）. Accordant results by TOC a- nalysis method and by HPLC method was observed. Conclusion TOC is an easy, quick and accurate method for de- termination of procaine hydrochloride injection.

关 键 词：总有机碳分析法 盐酸普鲁卡因注射液 含量测定 

分 类 号：R927.2[医药卫生—药学]