血尿酸浓度与主动脉夹层的关系  

Relationship between blood concentration of uric acid and aortic dissection

作　　者：王岩[1] 黄玫[2] 马翔[1] 

机构地区：[1]新疆医科大学第一临床医学院,乌鲁木齐830054 [2]新疆昌吉回族自治州人民医院,新疆昌吉831100

出　　处：《岭南心血管病杂志》2014年第6期734-736,共3页South China Journal of Cardiovascular Diseases

基　　金：新疆维吾尔自治区科技支疆项目;省(部)级支持(项目编号:2013911118)

摘　　要：目的 应用病例对照研究方法探讨血尿酸浓度与主动脉夹层的相关性,进一步从临床生化角度探讨主动脉夹层发病的相关危险因素.方法 病例组为新疆医科大学临床医学院自2012年8月至2014年6月收治的主动脉夹层患者160例;对照组选择同期住院的体检健康者157名,排除合并主动脉夹层、痛风、严重肾功能不全等相关疾病.收集患者的一般资料、既往病史,入院时常规实验室检查包括：血脂分析、D-二聚体、血尿酸、C反应蛋白、血小板、白细胞、血糖等结果.分析主动脉夹层发病的相关危险因素.结果 病例组血尿酸浓度较对照组显著增高,差异有统计学意义[（343.08±136.10） mmol/L vs.（312.5±85.61） mmol/L,P=0.030].多因素非条件Logistic回归分析显示,高尿酸血症是主动脉夹层发病的危险因素（OR=1.231,95％CI：0.919-0.981,P=0.002）.结论 新疆地区人群中高尿酸血症可能为主动脉夹层的危险因素.Objectives To probe the relationship between aortic dissection and blood concentration of uric acid,and to further explore the pathogenesis of aortic dissection and its risk factors.Methods A case-control study was conducted on 160 cases with aortic dissection from August 2012 to June 2014 in the First Affiliated Hospital of Xinjiang Medical University and 157 healthy control cases （without aortic dissection,gout or severe kidney failure） in the same period.General information,medical history,routine laboratory test results （blood lipid,D-dimer,uric acid in blood,Creactive protein,platelets,white blood cells,blood glucose and others） were recorded.Risk factors and the pathogenesis of aortic dissection were analyzed.Results Blood concentration of uric acid was significantly higher in patients with aortic dissection than in control cases [（343.08±136.10） mmol/L vs.（312.5±85.61） mmol/L,P=0.030].Multivariate unconditional Logistic regression indicated that hyperuricemia was an independent risk factor of aortic dissection （OR =1.231,95％CI：0.919-0.981,P=0.002）.Conclusions Hyperuricemia may be a risk factor of aortic dissection in Xinjiang.

关 键 词：主动脉夹层 血尿酸 危险因素 

分 类 号：R543.16[医药卫生—心血管疾病]