上海地区人偏肺病毒在儿童急性呼吸道感染的研究  

Study on human metapneumovirus in children with acute respiratory tract infection in Shanghai

作　　者：徐梅佳[1] 谢志萍[2] 高寒春[2] 叶剑敏[3] 杨子珍[4] 宋靖荣[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院儿科,上海201999 [2]中国疾病预防控制中心病毒病预防控制所 [3]上海交通大学医学院附属新华医院 [4]上海市普陀区中心医院

出　　处：《中国妇幼保健》2014年第36期6037-6038,共2页Maternal and Child Health Care of China

基　　金：国家自然科学基金〔81100005〕

摘　　要：目的：了解上海地区急性呼吸道感染病例中人偏肺病毒（HMPV）的感染情况,并对其临床特点进行初步分析。方法：2012年1-12月采集上海地区3家重点医院门、急诊和住院呼吸道感染病例标本271份,收集相关临床资料;采用PCR或RT-PCR方法对271份呼吸道标本检测包括HMPV在内的9种呼吸道病毒核酸。结果：271份标本中检出阳性标本7份,核酸阳性率为2.5%,〈6个月患儿HMPV阳性检出2例,检出率为2.1%,6-11个月患儿1例,检出率为1.6%,12-23个月患儿1例,检出率为2.0%,24-35个月患儿1例,检出率为5.3%,36-47个月患儿0例,≥48月2例,检出率为9.1%,各年龄组间检出率的差异无统计学意义。结论：HMPV是引起上海地区发热呼吸道病毒感染的主要病原体,也是引起儿童严重急性呼吸道病毒感染的主要病原之一。Objective： To understand human metapneumovirus infection status in children with acute respiratory tract infection in Shanghai,preliminarily analyze the clinical characteristics. Methods： A total of 271 samples of respiratory tract infection were collected from outpatient departments,emergency departments and inpatient departments of three key hospitals in Shanghai from January to December in 2012; the related clinical data were collected; PCR or RT- PCR was used to detect nine nucleic acids of respiratory viruses in 271 samples,including metapneumovirus. Results： Among 271 samples,7 samples were positive,the positive rate of nucleic acids was 2. 5%. The detection rates of human metapneumovirus in children under six months,aged 6- 11 months old,12- 23 months old,24- 35 months old,48 months or more than 48 months were 2. 1%（ two children）,1. 6%（ one child）,2. 0%（ one child）,5. 3%（ one child） and 9. 1%（ two children）,respectively; among the children aged 36- 47 months old,no one was found with positive human metapneumovirus; there was no statistically significant difference among the children in different age groups. Conclusion： Human metapneumovirus is the main pathogen of respiratory tract infection,which is also one of main pathogens of acute respiratory tract infection in children.

关 键 词：呼吸道感染 人偏肺病毒 儿童 

分 类 号：R725[医药卫生—儿科]