150例头孢哌酮不良反应文献分析  

Literature review and analysis of 150 cases of cefoperazone sodium

作　　者：上官丹罡[1] 龙明辉[1] 伍奕[1] 刘敏[2] 杨立平[1] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013 [2]中南大学湘雅医院,湖南长沙410013

出　　处：《中国医院药学杂志》2014年第23期2040-2043,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家十二五"重大新药创制"科技重大专项(编号:2011ZX09201-101-3)

摘　　要：目的:探讨注射用头孢哌酮钠不良反应的一般规律,为临床安全合理用药提供参考。方法:采用文献回顾性研究方法,对150例头孢哌酮不良反应患者的临床资料进行统计分析和总结。结果:头孢哌酮不良反应类型多,且可能涉及多个器官和系统,其中以变态反应和双硫仑样反应居多。结论:医护人员应当加强对头孢哌酮的用药监护,发生不良反应时要及时做出处理;尤其要叮嘱患者用药前后禁止饮酒,减少不良反应的发生。OBJECTIVE To investigate the adverse reactions induced by cefoperazone sodium and provide reference for ra-tional drug use. METHODS 150 medical records of adverse reaction induced by cefoperazone sodium were summarized and ana- lyzed. RESULTS The major adverse reactions were allergy and disulfiram-like reactiorL The adverse reactions may involve multiple organs and systems. CONCLUSION The medical staff should strengthen the pharmaceutical care of cefoperazone sodi- um and tell patients not to drink alcohol before and after treatment.

关 键 词：头孢哌酮 不良反应 双硫仑样反应 

分 类 号：R969[医药卫生—药理学]