矩阵实验室在拟合构建药动学三室模型中的应用  

Application of MATLAB in establishing three-compartment pharmacokinetic model

作　　者：陈伟[1] 王宇[1] 费小非[1] 谢兰桂[2] 李国辉[1] 

机构地区：[1]中国医学科学院肿瘤医院,北京100021 [2]中国食品药品检定研究院,北京100050

出　　处：《中国医院药学杂志》2014年第23期2056-2060,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:使用矩阵实验室(MATLAB)对符合三室模型的实验数据进行非线性拟合,考察MATLAB对于复杂非线性曲线的拟合程度,建立三室模型的常规拟合方法。方法:采用白及多糖家兔血浆药物浓度,使用MATLAB编写拟合程序,采用拟合结果最优的nlinfit函数进行非线性拟合,使用求解方程组的方法计算药动学参数。结果:计算结果与3P97软件进行比较,结果显示两者无显著性差异。结论:拟合程序可用于三室模型常规拟合。OBJECTIVE To establish the conventional fitting model through investigating the fitting degree of Matrix Labo- ratory（MATLAB） for complex nonlinear curve. IVIETItOI）S MATLAB was used to develop the fitting program, and the best fitting nlinfit function was employed for nonlinear fitting. After that, solving-equations method was introduced into calculation of pharmacokinetic parameters. RESULTS There was no significant difference between the pharmacokinetic parameters calcu- lated by the MATLAB program and the ones by the 3P97 program. CONCLUSION MATLAB fitting program can be used for the conventional fitting of three-compartment model.

关 键 词：药动学 三室模型 非线性拟合 矩阵实验室 

分 类 号：R945[医药卫生—微生物与生化药学]