碘仿原位凝胶的含量测定方法建立  

Establishment of a determination method for iodoform in-situ gel

作　　者：刘宁[1] 马守栋[2] 李明春[2] 程艳芹[2] 赵丽艳[2] 毛章 

机构地区：[1]青岛大学医学院,青岛266000 [2]解放军第401医院,青岛266071 [3]大连医科大学,大连116000

出　　处：《药物分析杂志》2014年第12期2261-2263,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的：建立紫外分光光度法测定碘仿原位凝胶的含量。方法：以乙醇为溶剂,在341 nm波长下测定碘仿原位凝胶的含量。通过精密度试验、回收率试验、稳定性试验等方法学研究,建立紫外分光光度法测定碘仿原位凝胶的含量。结果：碘仿测定的线性方程为Y=0.0065X＋0.007（r=0.9993）,检测浓度在35.6-119.6μg·m L^-1范围内与吸光度具有良好的线性关系,平均回收率（n=9）为100.2%。结论：建立的方法可用于碘仿原位凝胶的含量检测。Objective：To establish a method for the determination of iodoform in - situ gel by ultraviolet spectrophotometry, Methods： The contents of iodoform in - situ gel were determined at 341 nm with ethanol as the solvent by ultraviolet spectrophotometry. The method for determination of iodoform in - situ gel was achieved through the in- vestigation of precision, recovery and stability by ultraviolet sepectrophotometry. Results：The linear equation was Y = 0. 0065X ＋ 0. 007 （ r = 0. 9993 ） , and the calibration curve of iodoform was linear when its concentration range was 35.6 - 119.6 μg · mL^-1（ r = 0. 9993 ）. The average recovery rate （ n = 9） was 100.2%. Conclusion： The meth- od can be used for determination of iodoform in - situ gel.

关 键 词：抗菌消炎药 碘仿 碘仿原位凝胶 紫外分光光度法 医院制剂测定 

分 类 号：R917[医药卫生—药物分析学]