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作 者:王昊[1] 徐保平[1] 刘秀云[1] 胡英惠[1] 任亦欣[2] 申昆玲[1]
机构地区:[1]首都医科大学附属北京儿童医院国家临床重点专科小儿呼吸专业、国家呼吸系统疾病临床医学研究中心呼吸科,北京100045 [2]首都医科大学附属北京儿童医院国家临床重点专科小儿呼吸专业、国家呼吸系统疾病临床医学研究中心哮喘中心,北京100045
出 处:《中国实用儿科杂志》2014年第12期936-939,共4页Chinese Journal of Practical Pediatrics
基 金:国家科技支撑计划(2012BAI03B02)
摘 要:目的探讨儿童支气管扩张症临床表现、影像学及肺功能方面特点,分析病因构成,了解疾病预后。方法回顾性总结172例支气管扩张症患儿的临床表现、影像学、肺功能特点及病因,对部分患儿进行随访。结果支气管扩张症患儿临床主要表现为咳嗽、咯痰、生长发育受限、杵状指等。胸部X线诊断支气管扩张症的检出阳性率(4.42%)显著低于高分辨率CT(HRCT)的100%。存在免疫缺陷、闭塞性细支气管炎及原发性纤毛运动障碍的患儿在HRCT中弥漫性支气管扩张较其他病因更显著(P<0.05)。76.92%的患儿肺功能异常。65.70%的患儿可以发现潜在病因,以肺部感染(31.40%)为主。门诊随访患儿FEV1%随病程的延长以每年1.28%的速度下降。其中1例临床症状、HRCT、肺功能均有好转。结论儿童支气管扩张症临床表现没有明显特异性。大部分患儿可以发现潜在病因,以肺部感染最为常见。对于临床怀疑支气管扩张症的患儿应尽早进行HRCT检查,积极寻找潜在病因。支气管扩张症患儿的肺功能可随着病程的进展缓慢下降。部分患儿在临床症状、HRCT及肺功能上可有好转。Objective To investigate the general characteristics,undrelying causative factors and prognosis of bronchi-ectasis in chilren.MethodsA total of 172 chilren diagnosed with bronchiectasis were included in the study. Demo-graphics,clinical data,HRCT,lung function,and underlying etiology were collected and retrospectively analyzed. Partof the patients were followed up.ResultsCough and expectoration were the two most common symptoms. Chest X-raywas significantly less sensitive(4.42%)than HRCT(100%)scan in diagnosis of bronchiectasis. Immunodeficiency,bronchiolitis obliterans and primary ciliary dyskinesia were the three main etiology causing widespread distribution inHRCT(P〈0.05). Lung functions in 76.92% of the patients were abnormal. The underlying etiologies were identified in113 patients(65.70%),and pulmonary infecion(31.40%)was the most common. It was found that FEV1 decreased by1.28% per year with the extension of the course in the follow-up patients. There was improvement of HRCT in one pa-tient whose symptom and lung fuction were also improved.ConclusionBronchiectasis usually presents nonspecificsymptoms. Most patients can be found with the underlying causes,and pulmonary infection is the most common cause.HRCT is needed as early as possible in children with chronic respiratory symptoms. FEV1% declines slowly with thecourse extended. Part of the bronchiectasis children can be improved.
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