复方氨酚烷胺胶囊中对乙酰氨基酚的溶出度测定方法探讨  

Investigation on Determination Method of Acetaminophen Solubility in Compound Paracetamol and Amantadine Hydrochloride Capsules

作　　者：周泉[1] 卢小兰[1] 李全良[1] 黄富宏[1] 

机构地区：[1]江苏省扬州市第一人民医院,江苏扬州225009

出　　处：《中国药业》2014年第24期85-86,共2页China Pharmaceuticals

摘　　要：目的建立复方氨酚烷胺胶囊中对乙酰氨基酚的溶出度测定方法。方法采用转篮法,以0.1 mol/L盐酸溶液为溶出介质,转速为100 r/min,30 min时取样,在257 nm波长处测定紫外吸光度。结果对乙酰氨基酚质量浓度在0.500 2-50.02μg/m L范围内与吸光度值线性关系良好,线性回归方程为A=71.486C＋0.6992（r=1.0000）,平均回收率为101.31%,RSD为0.72%（n=6）。结论该方法操作简单,结果准确,可作为该制剂的溶出度测定方法。Objective To establish the solubility determination method of acetaminophen in Compound Paracetamol and Amantadine Hydrochloride Capsules. Methods The rotating basket method was adopted with 0. 1 mol/L hydrochloric acid solution as the dissolution medium. The sample was extracted at a rotating speed of 100 r/min and the ultraviolet absorbance was detected at the wavelength of257 nm. Results The mass concentration range of acetaminophen in the range of 0. 500 2- 50. 02 μg/m L showed good linear relationship with the peak area,the linear equation was A = 71. 486 C ＋ 0. 699 2（r = 1. 000 0）. The average recovery rate was101. 31%,RSD 0. 72%（n = 6）. Conclusion This method is simple to operate and accurate in results,which can be used as the solubility determination method of this preparation

关 键 词：复方氨酚烷胺胶囊 对乙酰氨基酚 溶出度 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学] R971.1