肾气亏虚型OA未病临床诊断试验的初步研究  

Preliminary study on disease clinical diagnostic test on OA with the kidney qi deficiency type

作　　者：宋庆慧[1] 王金洪[1] 何丽清 杨丽平[1] 朱嘉[1] 李莉[1] 马渊[1] 孔焕宇[1] 张万强[1] 

机构地区：[1]中国中医科学院望京医院,北京100102 [2]朝阳区八里庄社区卫生服务中心,北京100025

出　　处：《中国中医基础医学杂志》2014年第12期1657-1660,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：首都医学科技发展基金项目(SF-2007-Ⅰ-06)

摘　　要：目的:研究骨性关节炎(OA)患者尿液中Ⅱ型胶原C-端肽(CTX-Ⅱ)、血清中软骨寡聚基质蛋白(COMP)水平与病变严重程度的相关性,探讨其作为OA早期诊断及病情评估指标的价值和意义。方法:采用ELISA方法测定OA患者、类风湿关节炎患者及同期确诊的健康人的尿液中CTX-Ⅱ和血清中COMP水平。结果:与健康人群组比较,肾气亏虚型OA未病组与肾气亏虚型OA已病组CTX-Ⅱ含量增加,差异有统计学意义;肾气亏虚型OA未病组、肾气亏虚型OA已病组与类风湿关节炎患者组COMP含量增加,差异有统计学意义。结论:CTX-Ⅱ和COMP可作为OA辅助检查指标用于OA的早期诊断。Objective： Investigating the correlation between the levels which of CTX-Ⅱ in urine and COMP in serum and severity of osteoarthritis, to explore the value and significance of the early diagnosis of OA. Methods ： The levels of CTX- Ⅱ and COMP in urine were analyzed by enzyme-linked immunosorbent assay （ELISA） in patients with OA, RF and healthy people. Results ：① CTX - Ⅱ levels between groups compared with the healthy group ： The group of kidney deficiency of the latent OA significant difference; The group of kidney deficiency of OA significant difference;② COMP levels between groups compared with the healthy group ： The group of kidney deficiency of the latent OA significant difference ; The group of kidney deficiency of OA significant difference; The group of rheumatoid arthritis significant difference. Conclusion ： CTX - Ⅱ and COMP can be used as OA auxiliary examination index for early diagnosis of osteoarthritis （ OA ） , should be closely combined with clinical and other inspection, and rule out other diseases, in order to make the correct diagnosis.

关 键 词：骨性关节炎 Ⅱ型胶原C-端肽(CTX-Ⅱ) 软骨寡聚基质蛋白(COMP) 肾气亏虚型 

分 类 号：R684.3[医药卫生—骨科学]