CD36 rs3211956和rs7755单核苷酸多态性与早发冠心病的相关性  

The Association of CD36 rs7755 and rs3211956 Single Nucleotide Polymorphism with Premature Coronary Heart Disease

作　　者：赵伟伟[1] 车京津[1] 张彦彦[1] 邵元霞[1] 王俊乾[1] 

机构地区：[1]天津医科大学第二医院心脏科,300211

出　　处：《天津医药》2014年第12期1197-1202,共6页Tianjin Medical Journal

摘　　要：目的探讨早发冠状动脉粥样硬化性心脏病(CHD)的危险因素,及CD36基因rs7755和rs3211956单核苷酸多态性(SNP)与早发CHD的相关性。方法连续筛选冠状动脉造影证实的早发冠脉严重三支病变者(病变组)102例及冠脉造影正常者(正常组)72例,对比2组CHD的传统危险因素,并用质谱法检测所有入选者CD36 rs7755和rs3211956位点基因型,分析早发CHD的独立危险因素。结果传统危险因素中,男性、糖尿病、高血压、高低密度脂蛋白胆固醇(LDL-C)及低高密度脂蛋白胆固醇(HDL-C)是早发CHD的独立危险因素。病变组中rs3211956的GT基因型分布低于正常组(χ2=8.042,P=0.005),而TT基因型分布高于正常组(χ2=6.191,P=0.014);TT基因型者较含G等位基因者的体质指数(BMI)水平增高(P=0.037)。病变组rs7755的G等位基因的频率高于正常组(χ2=3.636,P=0.047);GG基因型的BMI水平高于A等位基因携带者(P<0.001),而HDL-C水平低于另两种基因型者(P<0.001)。Logistic回归分析显示在分别调整了混杂因素后,rs3211956基因型GG、TT及rs7755基因型GG、GA均为早发CHD的独立危险因素。结论 CD36 rs3211956、rs7755的SNP可能是致早发CHD的独立危险因素,且可能通过影响BMI和HDL-C而影响早发CHD的发生。Objective To investigate the risk factors of premature atherosclerotic three-vessel coronary artery dis-ease（CHD）, and the association between single nucleotide polymorphism（SNP） of CD36 rs3211956, rs7755 and prematureCHD. Methods Patient with premature three-vessel coronary artery disease（n=102） which were confirmed by consecutivecoronary angiogram（lesion group） and patients（n=72） without CHD（control group） were enrolled in the study. ConventionalCHD risk factors were compared between the two groups as well as SNPs of CD36 rs3211956 and rs7755 to disclose inde-pendent risk factor for CHD, which were measured by mass spectrometry. Results Among the conventional CHD risk fac-tors, male, HBP, high LDL-C, low HDL-C were independent risk factors of premature CHD. The GT genotype proportion ofrs3211956 was significantly lower（χ2=8.042,P =0.005） in the lesion group than that in control group while the TT genotypeproportion is significantly higher in lesion group compared with that in control group（χ2=6.191,P =0.014）. Patients with theTT genotype have higher score of BMI than patients with GG or GT genotype（P =0.037）. The G allele proportion of rs7755 inthe lesion group was significantly higher than control group（χ2=3.636, P=0.047）. Patients of the GG genotype have higherscores of BMI but lower level of HDL-C than those with AA or AG genotype（P0.001）. Logistic regression analysis re-vealed that after excluding a number of confounding factors, GG and TT genotype of rs3211956 and GG and GA genotype ofrs7755 were respectively one of the independent risk factors for premature CHD. Conclusion The SNPs of CD36 rs7755 and rs3211956 may be the independent risk factors of premature coronary heart disease and might affect the the onset ofCHD by affectting BMI and HDL-C.

关 键 词：冠心病 多态性 单核苷酸 抗原 CD36 危险因素 rs3211956 rs7755 

分 类 号：R541.4[医药卫生—心血管疾病]