基因修饰的间充质干细胞临床研究进展  

Clinical Research Progress of Genetically Modified Mesenchymal Stem Cells

作　　者：孙辉[1] 孙涛[1] 

机构地区：[1]海军总医院消化内科,北京100048

出　　处：《生物技术通讯》2014年第6期867-870,共4页Letters in Biotechnology

摘　　要：基因修饰的间充质干细胞(MSC)可有效地提高移植后细胞存活率,使细胞有效聚集于损伤部位。通过不断优化干细胞和载体选择,有效导入特定基因到MSC内,表达特定蛋白,可用于治疗获得性和遗传性疾病。我们就相关进展及问题做简要阐述,以期为基因修饰的MSC临床应用研究提供借鉴。Genetically modified mesenchymal stem cells（MSC） can effectively increase the survival of transplant？ed cells, and promote therapeutic cells aggregation at the site of injury. Through effective introduction of specific genes by continuous optimizing the selection of stem cells and vectors, MSC can express specific proteins, and can be used for the treatment of acquired or inherited diseases. In this paper, we elaborated the progress and is？sues in order to provide reference for clinical application of mesenchymal stem cells genetically modified.

关 键 词：基因修饰 间充质干细胞 临床治疗 

分 类 号：R25[医药卫生—中医内科学] R45[医药卫生—中医学]