白细胞介素17A和白细胞介素23在肺结核合并糖尿病患者外周血中的表达及意义  

Expression and clinical significance of serum IL-17A and IL-23 in pulmonary tuberculosis patients with diabetes mellitus

作　　者：叶宁华 罗勇强 林东子 曾今诚[3] 

机构地区：[1]东莞市中医院,广东东莞523000 [2]东莞市慢性病防治院,广东东莞523008 [3]广东医学院广东省医学分子诊断重点实验室,广东东莞523808

出　　处：《实验与检验医学》2014年第6期664-666,共3页Experimental and Laboratory Medicine

基　　金：广东省医学科研基金资助项目(B2013427);东莞市科技计划项目(201450715200503)

摘　　要：目的探讨肺结核合并糖尿病(PPTDM)患者外周血血清白细胞介素17A(IL-17A)和白细胞介素23(IL-23)含量并分析其临床意义。方法 ELISA检测30例PPTDM患者、30例肺结核(PTB)患者、30例糖尿病(DM)患者和26例健康志愿者(HV)外周血血清IL-17A和IL-23含量,并分析其相关性。结果 PPTDM组血清IL-17A均显著高于PTB组、DM组和HV组,而血清IL-23含量均显著低于PTB组、DM组和HV组(P<0.05)。PTB组血清IL-17A含量均显著高于DM组和HV组,而血清IL-23含量均显著低于DM组和HV组(P<0.05)。DM组和HV组血清IL-17A和IL-23含量差异均无统计学意义(P>0.05)。不同临床起病形式PPTDM患者中血清IL-17A和IL-23含量存在差异,DM-PTB组血清IL-17A含量显著高于PTBDM组,而血清IL-23含量显著低于PTB-DM组(P<0.05)。PPTDM患者组血清IL-17A含量和IL-23含量无明显相关性(P>0.05)。结论 IL-17A和IL-23在PPTDM疾病进展中可能具有重要的作用。Objective To detect serum IL-17A and IL-23 levels and analysis their clinical significance in pulmonary tuber-culosis patients with diabetes mellitus （PPTDM）. Methods Enzyme-linked immunosorbent assay （ELISA） was used to detect serum IL-17A and IL-23 levels in 30 PPTDM patients, 30 pulmonary tuberculosis （PTB） patients, 30 diabetes mellitus （DM） pa-tients and 30 healthy volunteers（HV）. Pearson correlation analysis was used to analyze the correlation of them. Results Serum IL-17A level was significantly higher, and IL-23 level lower in PPTDM patients than those in PTB, DM and HV groups （P〈0.05 re-spectively）. Serum IL-17A level was significantly higher, and IL-23 level lower in PTB patients than those in DM and HV groups （P〈0.05 respectively）. There was no significant difference of serum IL-17A level and IL-23 level between DM and HV groups （P〉0.05 respectively）. There was no significant correlation between serum IL-17A and IL-23 in PPTDM patients. Conclusion IL-17A and IL-23 may play an important role in PPTDM development.

关 键 词：肺结核 糖尿病 白细胞介素23 白细胞介素22 IL-23 

分 类 号：R521[医药卫生—内科学] R446.62[医药卫生—临床医学]