恩诺沙星微囊的制备及急性毒性试验  

Preparation and Acute Toxicity Test of Enrofloxacin Microcapsule

作　　者：卢素云[1] 钱林东[2] 王文梅[1] 繆金素 董伟[1] 孙志良[1,3] 

机构地区：[1]湖南农业大学动物医学院,湖南长沙410128 [2]云南农业职业技术学院,云南昆明650212 [3]湖南省兽药工程技术研究中心,湖南长沙410128

出　　处：《动物医学进展》2014年第12期99-103,共5页Progress In Veterinary Medicine

摘　　要：采用乳剂制备技术与微囊制备技术相结合的方法,以甲基纤维素和可溶性淀粉为囊材,制备了恩诺沙星微囊。结果表明,制备的恩诺沙星微囊分散状态良好,平均粒径为47.6μm,粒径分布在20μm^70μm范围内的微囊占88%,载药量为12.5%±0.40%,具有一定的缓释作用。急性毒性试验结果显示恩诺沙星微囊的LD50为5 968.81mg/kg,95%可信限为5 164.06mg/kg^6 978.86mg/kg,表明恩诺沙星微囊毒性很低,可以进行药效学试验研究。By combining drug emulsion preparation technique and microcapsule preparation method,enro-floxacin microcapsules enveloped by methyl cellulose and soluble starch were prepared.The results showed that enrofloxacin microcapsule dispersed well,and the average particle diameter was 47.6 μm with 88% of the microcapsules ranging from 20 μm to 70 μm.The microcapsules had a certain sustained release effect and the drug loading was 12.5%±0.40%.The acute toxicity tests showed that the LD50 for enrofloxacin microencapsulation was 5 968.81 mg/kg,95% confidence limit was 5 164.06 mg/kg to 6 978.86 mg/kg. It is concluded that the enrofloxacin microcapsule is safety,and can be used in clinical trials.

关 键 词：恩诺沙星 乳剂 微囊 稳定性 急性毒性 

分 类 号：S859.796[农业科学—临床兽医学] S856.9[农业科学—兽医学]