丹参注射液对非酒精性脂肪肝炎性因子IL-6、TNF-a的影响  

Injection of Non-Alcoholic Steatohepatitis Factor IL-6,TNF-a Salvia

作　　者：闫蕾[1] 张洪宇[1] 郭英君[1] 

机构地区：[1]宁夏自治区人民医院感染科,宁夏银川750001

出　　处：《亚太传统医药》2014年第24期10-11,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:观察丹参注射液对非酒精性脂肪肝(NAFLD)大鼠血清中白细胞介素(IL-6)及肿瘤坏死因子-a(TNF-a)的影响,从而验证丹参注射液对非酒精性脂肪肝治疗作用。方法 :将40只大鼠随机分为正常组、模型组、丹参小剂量组(400mg/kg)、丹参大剂量组(1 600mg/kg),8周后采用免疫组化法(ELLSA)检测各组大鼠血清中IL-6及TNF-a的水平。结果:模型组大鼠血清中IL-6、TNF-a水平明显增高;与模型组比较,不同剂量丹参组血清中IL-6、TNF-a水平显著降低。结论:丹参可能通过降低血清中IL-6、TNF-a水平,从而抑制肝细胞炎症反应,减轻肝组织损伤,达到治疗NAFLD的效果。Objective：Salvia serum of non-alcoholic fatty liver disease （NAFLD） in rats injections of interleukin （IL-6） and tumor necrosis factor-a （TNF-a） , so as to verify Salvia Injection on nowalcoholic fatty liver treatment. Methods：The 40 rats were ran domly divided into normal group, model group and low dose group salvia （400mg / kg）, Salvia high dose group （1 600mg / kg） , af ter 8 weeks using immunohistochemistry （ELLSA） detected group, serum levels of IL-6 and TNF-a in. Results：Model group, the serum IL-6, TNF-a levels were significantly higher ~ compared with the model group, each group with different doses of Salvia ser- um IL-6, TNF-a levels were significantly reduced. Conclusion：Salvia possible by reducing the serum II76, TNF-a levels,inhibiting the inflammatory response in liver cells,reducing damage to liver tissue , the therapeutic effect of NAFLD.

关 键 词：非酒精性脂肪肝 丹参 IL-6 TNF-A 

分 类 号：R285.53[医药卫生—中药学]