长方案IVF-ET周期获卵数与临床结局的关系分析  

Analysis of the Relationship between Egg Number and Clinical Outcome in IVF-ET Long Cycle

作　　者：王芳[1] 吴成平[1] 

机构地区：[1]郑州大学附属洛阳中心医院,河南洛阳471000

出　　处：《中国医学创新》2014年第33期37-40,共4页Medical Innovation of China

摘　　要：目的：探讨长方案体外受精-胚胎移植（IVF-ET）周期获卵数与临床结局的关系。方法：回顾分析本中心2013年2月-2014年6月743周期长方案IVF-ET的周期资料,根据获卵数分为六组,分别是A组：1-4个;B组：5-9个;C组：10-14个;D组：15-19个;E组：20-25个;F组：26-41个。比较各组年龄、BMI、Gn天数、Gn总量、临床妊娠率、可利用胚数、取消移植率等指标。结果：（1）随年龄增加,获卵数下降,Gn量增加。（2）各组间BMI比较差异无统计学意义（P〉0.05）。（3）Gn时间延长,获卵数增加。（4）可利用胚数及优质胚数A、B、C组与其他各组之间比较差异均有统计学意义（P〈0.05）,E组与F组间比较差异无统计学意义（P〉0.05）。显示获卵数增加,可利用胚胎数及优质胚数有增加趋势。但是在获卵数15个以上时,可利用胚数并未随获卵数增加而显著增加。（5）C组临床妊娠率最高,F组妊娠率最低。（6）获卵数5-14个时取消率低,获卵数20个以上时,因OHSS高风险取消移植率显著增高,获卵数1-4个时因内膜异常取消移植率增高。结论：年龄与获卵数、Gn量相关。Gn时间延长,获卵数增加。获卵10-14个时妊娠率最高,获卵数15个以上时,可利用胚数并未随获卵数增加而显著增加,然而OHSS风险增加。Objective：To explore the long plan in vitro fertilization-embryo transfer（IVF-ET） cycle for the relationship between number of eggs and clinical outcome.Method：The center 743 cycle long solution IVF- ET cycle data from February 2013 to June 2014 were retrospective analyzed.According to the number of eggs patients were divided into 6 groups, respectively were the group A： 1-4; the group B： 5-9; the group C： 10-14; the group D： 15-19; the group E： 20-25; the group F： 26-41. The age, BMI, the Gn days, total Gn dose, clinical pregnancy rate, the number of available embryos, the cancel rate of transplant of the groups were compared. Result：（1）Along with the age increasing, the egg number decreased, the Gn dose increased.（2）There was no significant difference compared between groups in BMI（P〈0.05）.（3）With Gn days prolonged the egg number increased.（4）Available embryos and good quality embryos between the group A, B, C and other groups had significant difference（P〈0.05）, but there was no significant difference between the group E and group F（P〉0.05）. It displayed that eggs by the increase in the number, the number of available embryos and good quality embryos had a tendency to increase. But when eggs more than 15 the available embryo number did not significantly increased with the increase of the eggs number.（5）The group C had the highest pregnancy rate, while the group F had the lowest.（6）Egg number 5-14 cancel rate was low, when eggs increased more than 20, the cancel rate of transplant and the OHSS high-risk increased significantly. For egg number 1-4 cancel transplant rate increased because abnormal endometrium.Conclusion：Age is related to the number of eggs and the Gn dose. With prolonged Gn days egg number increased. 10 eggs-14 pregnancy rate has highest clinical pregnancy rate, when egg number increased more than 15, available embryos do not significantly increased, however, the risk of OHSS increased.

关 键 词：体外受精-胚胎移植 获卵数 年龄 长方案 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]