17个短串联重复序列基因座杂合度与冲动攻击行为的相关性  

Association between the impulsive aggressive behaviors and the heterozygosity of 1 7 short tandem repeats loci

作　　者：何益民[1] 巴华杰[2] 杨春[3] 余海鹰[3] 赵汉清[3] 张书友[3] 

机构地区：[1]解放军第102医院检验科,常州213003 [2]常州市公安局刑警支队DNA实验室,213003 [3]解放军第102医院全军精神医学中心,常州201003

出　　处：《国际遗传学杂志》2014年第6期286-290,共5页International Journal of Genetics

基　　金：2013年南京军区医学科技创新课题（MS016）

摘　　要：目的：探讨短串联重复序列（STR）基因座杂合度与冲动攻击行为的关系。方法运用PowerPlex 18 D System荧光标记复合扩增试剂盒对249例冲动攻击行为军人个体与313例非攻击行为对照个体样本进行PCR复合扩增，然后应用ABI3130 XL型基因分析系统对扩增产物进行基因检测。比较两个群体中杂合子比率及17个STR基因座杂度性的差异。结果17个 STR 基因座在两个群体均符合Hardy-Weinberg平衡；两个群体中的杂合子比率差异无统计学意义（P＝0.533）；在 CSF1PO基因座冲动攻击行为组的杂合度显著低于对照组（P ＝0.035）；其余STR基因座两组的杂合度无统计学意义（P＞0.05）。结论 CSF1PO 基因座杂合性降低可能与冲动攻击行为的发生相关。Objective To investigate the relationship of the impulsive aggressive behavior and the heterozygosity of 1 7 short tandem repeats （ STRs ） loci .Methods The biological samples of 2 4 9 army-men with impulsive aggressive behavior and 3 1 3 healthy armymen without aggressive behavior were collect-ed .Then all of the sample were amplified by PowerPlex 1 8 D System and separated by electrophoresis to obtain the heterozygosity of 1 7 STRs loci in both groups .Results All the 1 7 STRs loci in both groups were found to coincide with Hardy-Weinberg equilibrium; The ratios of heterozygotes with in the 1 7 STR loci in both groups were not different （ P =0.5 3 3 ）;The heterozygosity of CSF 1 PO locus within armymen with impulsive aggressive behavior was lower than control group （ P =0.0 3 5 ）; The heterozygosity of both groups was not different in the other STR loci （ P 〉0.0 5 ） .Conclusion The reduction in heterozygosity of CSF 1 PO might associated with impulsive aggressive behavior .

关 键 词：人染色体 冲动攻击行为 短串联重复序列 杂合度 

分 类 号：R446.6[医药卫生—诊断学] R440[医药卫生—临床医学]