转化生长因子-β信号通路与心房颤动心房纤维化关系的研究进展  

Research progress in relationship between TGF-βsignal pathway and atrial fibrosis in atrial fibral-lition

作　　者：史航[1] 姜永日[1] 刘思奇[1] 刘宗泓[1] 张国伟[1] 王凯[1] 王柏春[1] 刘宏宇[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心血管外科,150001

出　　处：《国际遗传学杂志》2014年第6期315-318,324,共5页International Journal of Genetics

基　　金：黑龙江省自然科学基金（D201117）;黑龙江省政府博士后启动基金（LRB05258）;黑龙江省普通高等学校医学遗传学重点实验室开放基金项目

摘　　要：转化生长因子β（TGF-β）是细胞外基质最重要的调节因子，是目前已知的与纤维化关系最密切的生长因子，它通过Smad和非Smad信号途径发挥生物学作用。近年研究发现，TGF-β信号通路与心房纤维化的发生和发展密切相关，深入研究有助于为心房颤动心房纤维化的治疗提供新的思路。现就TGF-β信号转导通路与心房颤动心肌纤维化的关系进行综述。Transforming growth factor-βsignal pathway is believed to be the most important extra-cellular matrix regulator , which is also the most closely related to growth factor in the process of tissue fi-brosis currently , playing its biological function through Smad and non -Smad signaling pathway . Recent studies suggest that TGF-βsignal pathway is closely related with atrial fibrosis , and further studies will sup-ply a new approach for the treatment of atrial fibrosis in atrial fibrallition .Here is to make a review on the relationship between TGF-βsignal pathway and atrial fibrosis in atrial fibrallition .

关 键 词：心房颤动 心房纤维化 转化生长因子-β信号通路 

分 类 号：R541.75[医药卫生—心血管疾病]